Desmoglein shows extensive homology to the cadherin family of cell adhesion molecules.
Desmoglein shows extensive homology to the cadherin family of cell adhesion molecules.
复制标题
桥粒芯糖蛋白与细胞粘附分子钙粘蛋白家族具有广泛的同源性。
DOI：
10.1016/s0006-291x(05)80917-9
复制
发表时间：
1990
影响因子：
3.1
通讯作者：
Cowin,P
中科院分区：
文献类型：
--
作者：
Goodwin,L;Hill,JE;Raynor,K;Raszi,L;Manabe,M;Cowin,P
桥粒蛋白是桥粒的主要黏附成分。它也是至少一个抗原靶点的致病性抗体循环的患者的水疱性疾病的血清叶疱疮。为了研究桥粒黏附的分子基础，并进一步了解其在各种大泡性疾病中的破坏，我们克隆了编码桥粒蛋白细胞外结构域的四个cdna。预测的氨基酸序列与钙依赖性细胞粘附分子钙粘蛋白类具有广泛的同源性。粘粒蛋白代表了这个家族的一个新亚型。
Desmoglein is a major adhesive component of the desmosome. It is also at least one of the antigenic targets of pathogenic antibodies circulating in the sera of patients with the blistering diseasePemphigus foliaceus. To examine the molecular basis of desmosomal adhesion and to further our understanding of its disruption in various bullous disorders we have cloned cDNAs encoding four of the extracellular domains of desmoglein. The predicted amino acid sequence of these clones shows extensive homology with the cadherin class of calcium-dependent cell adhesion molecules. Desmoglein represents a novel subtype of this family.