Mutations affecting Ty-mediated expression of the HIS4 gene of Saccharomyces cerevisiae.
Mutations affecting Ty-mediated expression of the HIS4 gene of Saccharomyces cerevisiae.
复制标题
影响 Ty 介导的酿酒酵母 HIS4 基因表达的突变。
DOI：
10.1093/genetics/107.2.179
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发表时间：
1984
期刊：
影响因子：
3.3
通讯作者：
Fink,GR
中科院分区：
文献类型：
--
作者：
Winston,F;Chaleff,DT;Valent,B;Fink,GR
我们已经确定了7个非连锁基因(SPT基因)的突变，这些突变影响了HIS4基因OFS的5‘非编码区的TY和δ插入突变的表型。酿酒。选择突变体来抑制His 4-912δ，它是Ty912的一个单独的δ衍生物。HIS4上的其他Ty和δ插入被一些但不是所有SPT基因的突变所抑制。Onlyspt4取消HIS4处的非Ty插入。除了它们对TY和δ插入的影响外，几个SPT基因的突变还显示出一般细胞功能的缺陷-交配。DNA修复和生长。
We have identified mutations in seven unlinked genes (SPTgenes) that affect the phenotypes of Ty and δ insertion mutations in the 5′ noncoding region of theHIS4gene ofS. cerevisiae. Sptmutants were selected for suppression ofhis4-912δ, a solo δ derivative of Ty912. Other Ty and δ insertions atHIS4are suppressed by mutations in some but not all of theSPTgenes. Onlyspt4suppresses a non-Ty insertion atHIS4. In addition to their effects on Ty and δ insertions, mutations in severalSPTgenes show defects in general cellular functions—mating. DNA repair and growth.