Rapid glutamate release in the mediobasal hypothalamus accompanies feeding and is exaggerated by an obesogenic food
Rapid glutamate release in the mediobasal hypothalamus accompanies feeding and is exaggerated by an obesogenic food
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DOI：
10.1016/j.molmet.2013.02.001
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发表时间：
2013-04-01
影响因子：
8.1
通讯作者：
Schwartz, Michael W.
中科院分区：
文献类型：
--
作者：
Guyenet, Stephan J.;Matsen, Miles E.;Schwartz, Michael W.
下丘脑内侧基底核（MBH）在调节食物摄入和能量平衡中起着重要作用。虽然兴奋性神经递质谷氨酸与MBH的能量平衡调节有关，但摄食促进局部谷氨酸释放的假设尚未得到证实。为了验证这一假设，我们采用了谷氨酸生物传感器，测量谷氨酸浓度在1秒的时间间隔在有意识的，自由行为的大鼠。结果表明，喂养与MBH谷氨酸浓度的增加，发生在12秒内的口腔接触的食物颗粒，和谷氨酸的反应，一个可口的高脂肪颗粒大大夸大相对于食物。相比之下，在饮水或其他观察到的行为过程中没有观察到谷氨酸反应。这些研究结果表明，喂食与MBH中谷氨酸的快速释放有关，这种释放被致肥食物夸大，并且这种反应可能受到orosensory因素的刺激。(C)2013 Elsevier GmbH.在CC-BY-NC-ND许可下开放访问。
The mediobasal hypothalamus (MBH) plays a central role in the regulation of food intake and energy balance. Although the excitatory neurotransmitter glutamate is implicated in energy balance regulation by the MBH, the hypothesis that feeding elicits local glutamate release remains untested. To test this hypothesis, we employed a glutamate biosensor that measures glutamate concentrations at 1-s intervals in conscious, freely behaving rats. Results indicate that feeding is associated with an increase of MBH glutamate concentration that occurs within 12 s of oral contact with a food pellet, and the glutamate response to a palatable high-fat pellet is greatly exaggerated relative to chow. In contrast, glutamate responses were not observed during water ingestion or other observed behaviors. These findings indicate that feeding is associated with rapid release of glutamate in the MBH, that this release is exaggerated with an obesogenic food, and that this response is likely stimulated by orosensory factors. (C) 2013 Elsevier GmbH. Open access under CC-BY-NC-ND license.