Associations of urinary polycyclic aromatic hydrocarbons with age at natural menopause in US women aged 35-65, NHANES 2003-2012
Associations of urinary polycyclic aromatic hydrocarbons with age at natural menopause in US women aged 35-65, NHANES 2003-2012
复制标题
美国 35-65 岁女性尿液中多环芳烃与自然绝经年龄的关系，NHANES 2003-2012。
DOI：
10.1016/j.envpol.2018.09.109
复制
发表时间：
2018-12-01
影响因子：
8.9
通讯作者：
Zhang, Dan
中科院分区：
文献类型：
--
作者：
Huang, Yun;Guo, Jing;Zhang, Dan
多环芳烃（PAHs）介导的卵巢毒性已在动物实验中得到证实。然而，这一问题尚未在人类中进行评估。基于2003-2012年国家健康和营养检查调查（NHANES），数据分析仅限于1221名年龄在35-65岁的普通美国女性，数据完整。采用同位素稀释气相色谱/串联质谱法（GC-MS/MS）检测尿样中9种多环芳烃代谢物的含量。在访谈中获得了自我报告的绝经状态和绝经年龄信息。采用Cox比例风险回归评估多环芳烃水平与自然绝经之间的关系。与第一象限的女性相比,受试者1-Hydroxynapthalene最高四分位数的(风险比(人力资源)= 1.46,95%可信区间(CI) = 1.06 - 2.011, 2-Hydroxynapthalene (HR = 1.51, 95% CI = 1.12 - 2.05)和3-Hydroxyfluorene (HR = 1.51, 95% CI = 1.06 - 2.16),或在第二象限9-Hydroxyfluorene (HR = 1.53, 95% CI = 1.05 - 2.22),升高自然绝经的早期发病的风险。我们的研究结果表明，在普通美国女性中，尿中多环芳烃水平与自然绝经年龄的提前呈正相关。未来有必要进行前瞻性研究以确认因果关系。(C) 2018 Elsevier Ltd.版权所有。
Polycyclic aromatic hydrocarbons (PAHs) mediated ovarian toxicity has been demonstrated in animal experiments. However, this issue has not been assessed in humans. Based on the National Health and Nutrition Examination Survey (NHANES) 2003-2012, data analysis was restricted to 1221 general U.S. women aged 35-65 years with complete data of interest. Levels of nine PAH metabolites in spot urine specimens were measured by isotope dilution gas chromatography/tandem mass spectrometry (GC-MS/MS). Self-reported information on the menopause status and age at menopause were obtained during interview. Cox proportional hazards regression was employed to assess the associations between PAH levels and natural menopause. Compared with women in the first quartile, subjects in the highest quartile of 1-Hydroxynapthalene [hazard ratio (HR) = 1.46, 95% confidence interval (CI) = 1.06 to 2.011, 2-Hydroxynapthalene (HR = 1.51, 95% CI = 1.12 to 2.05) and 3-Hydroxyfluorene (HR = 1.51, 95% CI = 1.06 to 2.16), or in the second quartile of 9-Hydroxyfluorene (HR = 1.53, 95% CI = 1.05 to 2.22), had elevated risks of earlier onset of natural menopause. Our findings suggested positive associations between urinary PAH levels and earlier age at natural menopause in the general U.S. women. Prospective studies are warranted to confirm the causality in the future. (C) 2018 Elsevier Ltd. All rights reserved.