Sweepstakes reproductive success via pervasive and recurrent selective sweeps.
Sweepstakes reproductive success via pervasive and recurrent selective sweeps.
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DOI：
10.7554/elife.80781
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发表时间：
2023-02-20
期刊：
影响因子：
7.7
通讯作者：
Eldon B
中科院分区：
文献类型：
--
作者：
Árnason E;Koskela J;Halldórsdóttir K;Eldon B
以高早期死亡率为特征的高产自然种群比比皆是，但我们对其招募动态的了解有些初级。这种知识差距影响了我们对遗传变异、种群连通性、局部适应和高产种群恢复力的理解。抽奖式繁殖成功的概念是理解个体繁殖成功分布的关键，它假定个体繁殖产出存在相当大的差异和倾斜。然而，高繁殖力的生物体是否通过抽奖繁殖，如果是，中性抽奖和选择性抽奖的相对作用仍然需要确定。在这里，我们使用基于聚结的种群基因组数据统计分析来表明，选择性抽奖可能解释了繁殖旺盛的大西洋鳕鱼的招募动态。我们表明，Kingman聚类（模拟无抽奖）和Xi-Beta聚类（模拟随机抽奖），包括复杂的人口统计和背景选择，不能提供足够的数据拟合。Durrett-Schweinsberg合并理论提供了更强的解释力，在该理论中，新突变的反复出现和普遍存在的选择性扫描导致了选择性抽奖。我们的研究结果表明，抽奖繁殖和多次合并凝聚模型对于理解高繁殖力自然种群的遗传多样性是相关的和必要的。这些发现对了解鱼类种群的招募变异和高繁殖力生物的一般进化基因组学具有重要意义。
Highly fecund natural populations characterized by high early mortality abound, yet our knowledge about their recruitment dynamics is somewhat rudimentary. This knowledge gap has implications for our understanding of genetic variation, population connectivity, local adaptation, and the resilience of highly fecund populations. The concept of sweepstakes reproductive success, which posits a considerable variance and skew in individual reproductive output, is key to understanding the distribution of individual reproductive success. However, it still needs to be determined whether highly fecund organisms reproduce through sweepstakes and, if they do, the relative roles of neutral and selective sweepstakes. Here, we use coalescent-based statistical analysis of population genomic data to show that selective sweepstakes likely explain recruitment dynamics in the highly fecund Atlantic cod. We show that the Kingman coalescent (modelling no sweepstakes) and the Xi-Beta coalescent (modelling random sweepstakes), including complex demography and background selection, do not provide an adequate fit for the data. The Durrett–Schweinsberg coalescent, in which selective sweepstakes result from recurrent and pervasive selective sweeps of new mutations, offers greater explanatory power. Our results show that models of sweepstakes reproduction and multiple-merger coalescents are relevant and necessary for understanding genetic diversity in highly fecund natural populations. These findings have fundamental implications for understanding the recruitment variation of fish stocks and general evolutionary genomics of high-fecundity organisms.