Long-term effects of treatment and response in patients with chronic hepatitis C on quality of life. An international, multicenter, randomized, controlled study.
Long-term effects of treatment and response in patients with chronic hepatitis C on quality of life. An international, multicenter, randomized, controlled study.
复制标题
DOI：
10.1186/1471-230x-12-11
复制
发表时间：
2012-01-31
影响因子：
2.4
通讯作者：
DITTO-HCV Study Group
中科院分区：
文献类型：
--
作者：
Bezemer G;Van Gool AR;Verheij-Hart E;Hansen BE;Lurie Y;Esteban JI;Lagging M;Negro F;Zeuzem S;Ferrari C;Pawlotsky JM;Neumann AU;Schalm SW;de Knegt RJ;DITTO-HCV Study Group
丙型肝炎降低健康相关生活质量（HRQL），抗病毒治疗进一步降低。治疗成功后HRQL改善。该试验探讨了基于早期治疗反应给予个体化或标准治疗的患者HRQL的病程和相关因素。在基线（n = 192）和治疗结束后24周（n = 128）进行简短形式(SF)-36健康调查。基线时HRQL受年龄、参与中心、肝病严重程度和收入的影响。考察HRQL（随访时减去基线时的得分）的过程，只有一般健康维度增加。在这方面，复发或持续反应的患者与无反应者不同。男性和女性在身体疼痛的维度上有所不同。治疗方案对HRQL病程无影响。HRQL的主要决定因素为肝病严重程度、年龄、性别、参与中心和治疗反应。我们的研究结果不排除个体化治疗与标准治疗相比有更深远的负面影响，可能是由于个体化治疗组的高剂量和延长治疗时间造成的。抗病毒治疗可能对女性产生更强烈、更持久的负面影响。
Hepatitis C decreases health related quality of life (HRQL) which is further diminished by antiviral therapy. HRQL improves after successful treatment. This trial explores the course of and factors associated with HRQL in patients given individualized or standard treatment based on early treatment response (Ditto-study). The Short Form (SF)-36 Health Survey was administered at baseline (n = 192) and 24 weeks after the end of therapy (n = 128). At baseline HRQL was influenced by age, participating center, severity of liver disease and income. Exploring the course of HRQL (scores at follow up minus baseline), only the dimension general health increased. In this dimension patients with a relapse or sustained response differed from non-responders. Men and women differed in the dimension bodily pain. Treatment schedule did not influence the course of HRQL. Main determinants of HRQL were severity of liver disease, age, gender, participating center and response to treatment. Our results do not exclude a more profound negative impact of individualized treatment compared to standard, possibly caused by higher doses and extended treatment duration in the individualized group. Antiviral therapy might have a more intense and more prolonged negative impact on females.