Effects of nitrous oxide on motor evoked potentials recorded from skeletal muscle in patients under total anesthesia with intravenously administered propofol.
Effects of nitrous oxide on motor evoked potentials recorded from skeletal muscle in patients under total anesthesia with intravenously administered propofol.
复制标题
一氧化二氮对静脉注射异丙酚全麻患者骨骼肌运动诱发电位的影响。
DOI：
10.1097/00006123-199110000-00012
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发表时间：
1991
期刊：
影响因子：
4.8
通讯作者：
L. Symon
中科院分区：
文献类型：
--
作者：
D. Jellinek;M. Platt;D. Jewkes;L. Symon
研究了一氧化二氮（N_2O）对异丙酚（2，6-二异丙基苯酚）全凭静脉麻醉下运动诱发电位（MEP）的影响。MEP记录从第一背侧骨间肌的脚在9个科目;在其中两个，同时记录从第二背侧骨间肌的手和三角肌。单次经颅电刺激用于记录MEP。N2 O的影响进行了研究，浓度从20至70%。增加浓度的N2 O引起的发病潜伏期和下降的峰-峰幅度记录从脚的逐步增加。当N2 O浓度大于20%时，潜伏期值显示出显著增加（P值为0.05-0.005）。当N2 O浓度大于50%时，反应幅度显示出较基线显著降低（P值，0.05-0.005）。第二背侧骨间肌的手表现出一种模式的敏感性N2 O类似的第一背侧骨间肌的脚。在所用浓度下，三角肌的起始潜伏期和初始峰-峰振幅对N2 O不敏感。我们的结论是，N2 O可以用作麻醉辅助剂，在丙泊酚麻醉下的患者术中监测期间，N2 O浓度保持在50%以下，对MEP无显著有害影响。
The effect of nitrous oxide (N2O) on motor evoked potentials (MEPs) recorded from human subjects under total intravenous anesthesia with propofol (2,6-diisopropylphenol) was studied. MEPs were recorded from the 1st dorsal interosseous muscle of the foot in nine subjects; in two of these, simultaneous recordings were made from the 2nd dorsal interosseous muscle of the hand and from the deltoid muscle. Single transcranial electrical stimuli were used in recording the MEPs. The effects of N2O were studied at concentrations from 20 to 70%. Increasing concentrations of N2O caused a progressive increase in onset latency and a fall in the peak-to-peak amplitude of the MEPs recorded from the foot. Latency values showed a significant increase above the baseline at concentrations of N2O greater than 20% (P values, 0.05-0.005). The response amplitude showed a significant decrease from the baseline at concentrations of N2O greater than 50% (P values, 0.05-0.005). The 2nd dorsal interosseous muscle of the hand demonstrated a pattern of sensitivity to N2O similar to that of the 1st dorsal interosseous muscle of the foot. The onset latency and initial peak-to-peak amplitude of the deltoid muscle were insensitive to N2O at the concentrations used. We conclude that N2O can be used as an anesthetic adjunct without a significant deleterious effect on MEPs during intraoperative monitoring in patients under propofol anesthesia, providing concentrations are maintained below 50%.