The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease.
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease.
复制标题
DOI：
10.1038/cdd.2013.125
复制
发表时间：
2013-12
影响因子：
12.4
通讯作者：
中科院分区：
文献类型：
--
作者：
MiR-17/92簇是研究最深入的microRNA簇之一。自发现该专题组以来，人们对该专题组及其成员的兴趣一直在稳步增加，出版物数量呈指数级增长，仅在2012年就发表了1000多篇文章。最初被发现与肿瘤发生有关，近年来的研究工作发现，其成员在包括正常发育、免疫疾病、心血管疾病、神经退行性疾病和衰老在内的各种环境中扮演着意想不到的角色。鉴于其日益增长的重要性和不断扩大的调控作用，我们在这里回顾了关于该集群参与健康和疾病的最新知识体系，并对其成员可能调控的蛋白质编码和非编码转录本的全谱提供了一个新的视角。
The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the cluster and its members has been increasing steadily and the number of publications has grown exponentially since its discovery with more than 1000 articles published in 2012 alone. Originally found to be involved in tumorigenesis, research work in recent years has uncovered unexpected roles for its members in a wide variety of settings that include normal development, immune diseases, cardiovascular diseases, neurodegenerative diseases and aging. In light of its ever-increasing importance and ever-widening regulatory roles, we review here the latest body of knowledge on the cluster's involvement in health and disease as well as provide a novel perspective on the full spectrum of protein-coding and non-coding transcripts that are likely regulated by its members.
登录
查看更多内容
影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
3.3
作者：
De Santis, Giuseppe;Ferracin, Manuela;Granieri, Enrico
通讯作者：
Granieri, Enrico
影响因子：
7
作者：
Barski, Artem;Jothi, Raja;Zhao, Keji
通讯作者：
Zhao, Keji
影响因子：
3.3
作者：
Cui YH;Xiao L;Rao JN;Zou T;Liu L;Chen Y;Turner DJ;Gorospe M;Wang JY
通讯作者：
Wang JY
影响因子：
3.7
作者：
Adilakshmi T;Sudol I;Tapinos N
通讯作者：
Tapinos N