Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells
Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells
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DOI：
10.1016/j.ccr.2007.11.032
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发表时间：
2008-03-01
期刊：
影响因子：
50.3
通讯作者：
Brown, J. Martin
中科院分区：
文献类型：
--
作者：
Ahn, G-One;Brown, J. Martin
肿瘤血管系统来源于局部血管（血管生成）和骨髓（BM）来源的循环细胞（血管发生）的发芽。通过使用将肿瘤移植到照射的正常组织中以防止血管生成的模型系统，我们发现肿瘤不能在基质金属蛋白酶-9（MMP-9）敲除小鼠中生长，但通过移植野生型BM可以恢复肿瘤生长。内皮祖细胞对这一过程没有显著贡献。相反，来自移植BM的CD 11b阳性骨髓单核细胞负责接受野生型BM的MMP-9敲除小鼠中的肿瘤生长和未成熟血管的发育。我们的研究结果表明，MMP-9可能是一个重要的目标，辅助治疗，以提高肿瘤对放射治疗的反应。
Tumor vasculature is derived from sprouting of local vessels (angiogenesis) and bone marrow (BM)-derived circulating cells (vasculogenesis). By using a model system of transplanting tumors into an irradiated normal tissue to prevent angiogenesis, we found that tumors were unable to grow in matrix metalloproteinase-9 (MMP-9) knockout mice, but tumor growth could be restored by transplantation of wild-type BM. Endothelial progenitor cells did not contribute significantly to this process. Rather, CD11b-positive myelomonocytic cells from the transplanted BM were responsible for tumor growth and the development of immature blood vessels in MMP-9 knockout mice receiving wild-type BM. Our results suggest that MMP-9 could be an important target for adjunct therapy to enhance the response of tumors to radiotherapy.