Prevalence and stability of antibodies to 37 human papillomavirus types - A population-based longitudinal study
Prevalence and stability of antibodies to 37 human papillomavirus types - A population-based longitudinal study
复制标题
DOI：
10.1016/j.virol.2010.07.046
复制
发表时间：
2010-11-10
期刊：
影响因子：
3.7
通讯作者：
Neale, Rachel E.
中科院分区：
文献类型：
--
作者：
Antonsson, Annika;Green, Adele C.;Neale, Rachel E.
关于皮肤HPV类型随时间的血清稳定性的信息非常有限。我们在一项澳大利亚人群研究中调查了4.5年内37种不同HPV类型的血清阳性率和血清稳定性。对390名从未被诊断为SCC的人的血清和数据进行了分析，这些人在1992年、1993年和1996年采集了血液。86%的参与者在基线时对37种HPV类型中的至少一种血清阳性。HPV-4是血清阳性率最高的类型（41%），其次是HPV-38和HPV-8（均为33%）。超过90%的人在4年半的随访期间保持了基线血清状态。最高的血清稳定性观察HPV-88（99.7%保持血清阳性或血清阴性），而HPV-65是最不稳定的17%改变他们的血清状态在follow-up.Seroprevalence皮肤HPV类型是相对稳定的，随着时间的推移，和一个单一的措施可以作为一个合理的标志物的长期抗体状态。(C)2010年由Elsevier Inc.出版
Information about serostability of cutaneous HPV types over time is very limited. We investigated seroprevalence and serostability of 37 different HPV types over 4 1/2 years in an Australian population-based study. Sera and data were analyzed for 390 people who had never been diagnosed with SCC and had blood collected in 1992, 1993 and 1996.Eighty-six percent of participants were seropositive to at least one of the 37 HPV types at baseline. HPV-4 was the type with the highest seroprevalence (41%), followed by HPV-38 and HPV-8 (both 33%). Over 90% of people retained their baseline serostatus during the 4 1/2 year follow-up. Highest serostability was observed for HPV-88 (99.7% stayed seropositive or seronegative), while HPV-65 was least stable with 17% altering their serostatus during follow-up.Seroprevalence to cutaneous HPV types are relatively stable over time, and a single measure can be used as a reasonable marker of long-term antibody status. (C) 2010 Published by Elsevier Inc.