Regional cerebral blood flow and cerebrospinal fluid glutamate in leukoaraiosis
Regional cerebral blood flow and cerebrospinal fluid glutamate in leukoaraiosis
复制标题
脑白质疏松症的局部脑血流量和脑脊液谷氨酸水平
作者：
Minoru Oishi;Y. Mochizuki
抽象的。通过磁共振成像研究脑白质疏松症患者的脑血流和脑脊液氨基酸。研究对象为 10 名脑白质疏松且无明显脑梗塞的患者和 10 名磁共振成像未见异常的年龄匹配对照者。使用稳定氙计算机断层扫描方法测量局部脑血流量。脑白质疏松组脑白质疏松区域的血流量显着低于对照组相同区域。脑白质疏松组脑脊液谷氨酸浓度显着高于对照组。白质疏松区血流量与脑脊液谷氨酸浓度呈显着负相关。脑白质疏松症患者脑脊液谷氨酸浓度高被认为与缺血有关。
Abstract. Cerebral blood flow and cerebrospinal fluid amino acids were investigated in patients with leukoaraiosis on magnetic resonance imaging. Ten patients with leukoaraiosis and without significant cerebral infarction and ten age-matched controls without abnormality on magnetic resonance imaging were studied. The regional cerebral blood flow was measured using the stable xenon computed tomography method. The blood flow was significantly lower in the leukoaraiosis area in the leukoaraiosis group than in the same area in the control group. The cerebrospinal fluid glutamate concentration was significantly higher in the leukoaraiosis group than in the control group. There was a significant negative correlation between the blood flow in the leukoaraiosis area and the cerebrospinal fluid glutamate concentration. The high concentration of cerebrospinal fluid glutamate in patients with leukoaraiosis is considered to be related to ischaemia.