OXIDATION PHENOTYPE - A MAJOR DETERMINANT OF METOPROLOL METABOLISM AND RESPONSE
OXIDATION PHENOTYPE - A MAJOR DETERMINANT OF METOPROLOL METABOLISM AND RESPONSE
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DOI：
10.1056/nejm198212163072505
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
WOODS, HF
中科院分区：
文献类型：
--
作者：
LENNARD, MS;SILAS, JH;WOODS, HF
异喹胍氧化代谢的遗传多态性1是异喹胍血药浓度和抗高血压作用个体差异的主要原因。2不良羟化剂有尿异喹胍：4-羟基异喹比率高于20，而广泛羟化者的比率低于12.5.3，4在英国，弱羟化者表型的患病率约为9%，3但在不同种族群体中差异很大，从阿拉伯人的1%到香港华人的30%。5这种表型在美国的患病率尚未报告，但在加拿大的白人中，似乎……
GENETIC polymorphism in the oxidative metabolism of debrisoquine1is largely responsible for individual differences in its plasma concentration and antihypertensive effect.2Poor hydroxylators have urinary debrisoquine:4-hydroxydebrisoquine ratios that are higher than 20, whereas extensive hydroxylators have ratios that are less than 12.5.3,4The prevalence of the poor hydroxylator phenotype is about 9 per cent in the United Kingdom3but it varies widely among ethnic groups, from 1 per cent in Arabs to 30 per cent in Hong Kong Chinese.5The prevalence of this phenotype in the United States has not been reported, but among whites in Canada it appears to . . .