Glucose does not reverse impairments on spontaneous alternation induced by the noncompetitive NMDA antagonist MK-801.
Glucose does not reverse impairments on spontaneous alternation induced by the noncompetitive NMDA antagonist MK-801.
复制标题
葡萄糖不能逆转非竞争性 NMDA 拮抗剂 MK-801 引起的自发交替损伤。
DOI：
10.1006/nlme.1995.1010
复制
发表时间：
1995
影响因子：
2.7
通讯作者：
Gold,PE
中科院分区：
文献类型：
--
作者：
Lennartz,RC;Gold,PE
N-甲基-D-天冬氨酸（NMDA）拮抗剂已被证明会损害包括迷宫学习在内的各种任务的习得。本实验室先前报道，葡萄糖可逆转小鼠中竞争性NMDA拮抗剂NPC 12626给药引起的自发交替缺陷。本研究测试了葡萄糖逆转由非竞争性NMDA拮抗剂MK-801诱导的缺陷的能力。尽管皮下给予0.10 mg/kg MK-801导致自发交替功能缺陷，但葡萄糖（100和250 mg/kg）未逆转该损伤。葡萄糖逆转由两种NMDA拮抗剂引起的损伤的能力的这种差异可能反映了它们在NMDA受体复合物上的不同作用模式。
N-Methyl-D-aspartate (NMDA) antagonists have been demonstrated to impair acquisition in a variety of tasks, including maze learning. It was previously reported from this laboratory that glucose can reverse the deficits on spontaneous alternation resulting from administration of the competitive NMDA antagonist NPC 12626 in mice. The present study tested the ability of glucose to reverse deficits induced by the noncompetitive NMDA antagonist MK-801. Although subcutaneous administration of 0.10 mg/kg of MK-801 resulted in a deficit on spontaneous alternation, glucose (100 and 250 mg/kg) did not reverse the impairment. This difference in the ability of glucose to reverse the impairment caused by the two NMDA antagonists may reflect their different modes of actions at the NMDA receptor complex.