Ras-regulated signaling processes in Saccharomyces cerevisiae
Ras-regulated signaling processes in Saccharomyces cerevisiae
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DOI：
10.1016/s0959-437x(05)80302-8
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发表时间：
1991-10-01
影响因子：
4
通讯作者：
Broach, James R.
中科院分区：
文献类型：
--
作者：
Broach, James R.
分子遗传学已被证明是相当成功的，在确定组件的RAS介导的信号转导的酵母酿酒酵母，并在定义其相互作用的性质。最近，重点已转移到生物化学的方法作为鸟嘌呤核苷酸交换，GTdR刺激活性和Ras蛋白的翻译后修饰的过程都已在体外再现。
Molecular genetics has proved quite successful in identifying the components of RAS-mediated signal transduction in the yeast Saccharomyces cerevisiae and in defining the nature of their interactions. Recently, the emphasis has shifted to a biochemical approach as the processes of guanine nucleotide exchange, GTPase stimulation activity and post-translational modification of Ras proteins have all been reproduced in vitro.