The relationship between serum total cholesterol and all-cause or cause-specific mortality in a 17.3-year study of a Japanese cohort
The relationship between serum total cholesterol and all-cause or cause-specific mortality in a 17.3-year study of a Japanese cohort
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DOI：
10.1016/j.atherosclerosis.2006.01.024
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发表时间：
2007-01-01
期刊：
影响因子：
5.3
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
--
作者：
Okamura, Tomonori;Tanaka, Hideo;Ueshima, Hirotsugu
没有研究表明日本人群中高胆固醇血症与全因死亡率之间存在正相关关系。因此，对从日本各地随机选择的9216名30岁或以上的参与者进行了为期17.3年的队列研究。在这两个最低（<4.14 mmol/L，160 mg/dl）和最高（> 6.71 mmol/L，260 mg/dl）总胆固醇（TC）组，TC与全因死亡风险呈正相关（风险比（HR）1.19; 95%置信区间（CI）分别为1.03 - 1.37和1.36（95% CL 1.05 - 1.77））。最低TC组肝病风险增加（FIR 3.03; 95%CI 1.70 - 5.43），而最高TC组冠心病风险增加（HR 3.8 1; 95%CI，1.70 - 5.43）。在排除整个随访期间因肝脏疾病导致的死亡和随访前5年内的全因死亡后，最低TC组的HR增加消失（HR 1.05; 95% CI，0.89 - 1.24）。尽管似乎达到了临界点，但她的研究结果显示，高胆固醇血症与日本的全因死亡率呈正相关。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
No study has shown a positive relationship between hypercholesterolemia and all-cause mortality in the Japanese population. Therefore, a cohort study of 17.3 years' duration was conducted on 9216 participants aged 30 years or older, selected randomly from throughout Japan. In both the lowest (< 4.14 mmol/L, 160 mg/dl) and highest (> 6.71 mmol/L, 260 mg/dl) total cholesterol (TC) groups, there was a positive association between TC and risk of all-cause mortality (hazard ratio (HR) 1.19; 95% confidence interval (CI), 1.03-1.37 and 1.36 (95% CL 1.05-1.77), respectively). The lowest TC group had an increased risk of liver disease (FIR 3.03; 95% Cl 1.70-5.43), whereas the highest TC group had an increased risk of coronary heart disease (HR 3.8 1; 95% CI, 1.70-5.43). After exclusion of deaths due to liver disease during the entire follow-up period and all-cause deaths within the first 5 years of follow-up, the increased HR in the lowest TC group disappeared (HR 1.05; 95% CI, 0.89-1.24). Although the cut-off point seemed to be hit,her than that for Western populations, hypercholesterolemia was shown to be positively associated with all-cause mortality in Japan. (c) 2006 Elsevier Ireland Ltd. All rights reserved.