Posterior brain white matter abnormalities in older adults with probable mild cognitive impairment
Posterior brain white matter abnormalities in older adults with probable mild cognitive impairment
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DOI：
10.1080/13803395.2014.985636
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发表时间：
2015-01-02
影响因子：
2.2
通讯作者：
Paul, Robert H.
中科院分区：
文献类型：
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作者：
Cooley, Sarah A.;Cabeen, Ryan P.;Paul, Robert H.
目的：许多轻度认知障碍（MCI）的神经影像学文献都只关注与阿尔茨海默病相关的区域。很少有研究检查其他大脑区域的白色异常，包括与视觉处理相关的区域，尽管有证据表明其他大脑异常出现在疾病的早期阶段。方法：扩散张量成像（DTI）被用来检查参与者（n = 44），完成基线成像的一部分，纵向健康老龄化研究。根据蒙特利尔认知评估（莫卡）的分数，参与者被分为两组，MoCA是MCI的一种简单筛查工具。得分= 26的参与者被标记为认知健康。两个DTI指标进行了分析，包括分数各向异性（FA）和平均扩散率（MD）。采用多变量方差分析（MANOVA）比较舌回、楔叶、距嵴周围、梭状回和所有四个脑叶中白色物质的DTI值。回归分析研究了DTI指数和莫卡总分之间的关系。结果如下：结果显示，在可能MCI组中，楔叶、梭形、距突周围和枕叶的FA显著较低，而颞叶的MD显著较高。梭状FA和颞叶MD与莫卡总分显著相关。结论：结果表明，在可能患有MCI的个体中存在后部白色物质显微结构的改变。这些差异表明，白色异常是明显的个人与可能的MCI的区域以外的那些通常与阿尔茨海默氏症和前脑老化模式。
Objective: Much of the mild cognitive impairment (MCI) neuroimaging literature has exclusively focused on regions associated with Alzheimer's disease. Little research has examined white matter abnormalities of other brain regions, including those associated with visual processing, despite evidence that other brain abnormalities appear in these regions in early disease stages. Method: Diffusion tensor imaging (DTI) was utilized to examine participants (n = 44) that completed baseline imaging as part of a longitudinal healthy aging study. Participants were divided into two groups based on scores from the Montreal Cognitive Assessment (MoCA), a brief screening tool for MCI. Participants who scored = 26 were labeled cognitively healthy. Two DTI indices were analyzed including fractional anisotropy (FA) and mean diffusivity (MD). DTI values for white matter in the lingual gyrus, cuneus, pericalcarine, fusiform gyrus, and all four lobes were compared using multivariate analysis of variance (MANOVA). Regression analyses examined the relationship between DTI indices and total MoCA score. Results: Results revealed significantly lower FA in the probable MCI group in the cuneus, fusiform, pericalcarine, and occipital lobe, and significantly higher MD in the temporal lobe. Fusiform FA and temporal lobe MD were significantly related to total MoCA score after accounting for age and education. Conclusions: Results indicate that there are posterior white matter microstructural changes in individuals with probable MCI. These differences demonstrate that white matter abnormalities are evident among individuals with probable MCI in regions beyond those commonly associated with Alzheimer's disease and anterior brain aging patterns.