GlyProt: in silico glycosylation of proteins.

GlyProt: in silico glycosylation of proteins.
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DOI:
10.1093/nar/gki385
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发表时间:
2005-07-01
影响因子:
14.9
通讯作者:
von der Lieth CW
von der Lieth CW
中科院分区:
生物学2区
文献类型:
--
作者:
Bohne-Lang A;von der Lieth CW

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GlyProt()是一个基于网络的工具,能够将有意义的N-聚糖构象连接到已知三维(3D)蛋白质结构的所有空间可访问的潜在N-糖基化位点。计算了质量、可及表面和回转半径等物理化学性质的概率。这项服务的目的是提供快速访问可靠的糖蛋白3D模型,随后可以通过使用更精细的模拟进行改进,并通过将生成的模型与实验数据进行比较进行验证。
GlyProt () is a web-based tool that enables meaningful N-glycan conformations to be attached to all the spatially accessible potential N-glycosylation sites of a known three-dimensional (3D) protein structure. The probabilities of physicochemical properties such as mass, accessible surface and radius of gyration are calculated. The purpose of this service is to provide rapid access to reliable 3D models of glycoproteins, which can subsequently be refined by using more elaborate simulations and validated by comparing the generated models with experimental data.
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