Association between genotype at an exonic SNP in DISC1 and normal cognitive aging
Association between genotype at an exonic SNP in DISC1 and normal cognitive aging
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DOI：
10.1016/j.neulet.2005.07.004
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发表时间：
2005-11-25
影响因子：
2.5
通讯作者：
Deary, IJ
中科院分区：
文献类型：
--
作者：
Thomson, PA;Harris, SE;Deary, IJ
DISC1在海马体中表达，并已被确定为精神分裂症和双相情感障碍的可能遗传风险因素。这些精神疾病与学习和记忆受损有关。本研究调查了DISC1变异与11岁和79岁时相同的一般心理能力测试（Moray House测试）的认知功能以及11岁至79岁之间的认知变化之间的关联，来自Lothian出生队列1921（LBC1921）的425人。在79岁时还进行了记忆力，非语言推理和执行功能的测试。基因型的影响，在非同义单核苷酸多态性外显子11，rs821616，进行了研究。DISC1基因型对任何认知测量没有直接影响。然而，有一个显着的DISC1基因型的性别相互作用，在79岁时，在11岁的认知能力调整之前和之后的Moray House测试分数（p=0.034和0.043，分别）。在79岁时，Cys等位基因纯合子女性的认知能力评分显著低于男性，p=0.003。因此，DISC1的变化可能会影响认知老化，尤其是女性。(C)2005爱思唯尔爱尔兰有限公司保留所有权利。
DISC1 is expressed in the hippocampus and has been identified as a possible genetic risk factor for both schizophrenia and bipolar disorder. These psychiatric illnesses are associated with impaired learning and memory. This study investigates the association of variation in DISC1 with cognitive function on the same general mental ability test (Moray House Test) at age 11 and age 79, and cognitive change between ages 11 and 79, in 425 people from the Lothian Birth Cohort 1921 (LBC1921). Tests of memory, non-verbal reasoning and executive function were also administered at age 79. The effect of genotype at a non-synonymous single nucleotide polymorphism in exon 11, rs821616, was studied. There was no direct effect of DISC1 genotype on any cognitive measure. However, there was a significant DISC1 genotype by sex interaction on Moray House Test scores at age 79, both before and after adjustment for cognitive ability at age 11 (p=0.034 and 0.043, respectively). Women homozygous for the Cys allele had significantly lower cognitive ability scores than men at age 79, p=0.003. Variation in DISC1 may therefore affect cognitive aging especially in women. (C) 2005 Elsevier Ireland Ltd. All rights reserved.