Ionic mechanism of water receptors in the laryngeal mucosa of the rabbit.
Ionic mechanism of water receptors in the laryngeal mucosa of the rabbit.
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兔喉粘膜水受体的离子机制。
DOI：
10.2170/jjphysiol.27.27
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
T. Shingai
中科院分区：
文献类型：
--
作者：
T. Shingai
通过记录兔喉上神经纤维的单位放电，研究了不同离子对水反应的影响。阴离子对水的响应有很强的影响。所使用的无机阴离子分为两组。一组由抑制水反应的阴离子(抑制阴离子)组成，抑制作用序列为SCN-大于Br-大于CI-大于I-大于NO-3。另一种是促进水反应的阴离子(促进阴离子)，促进作用顺序是柠檬酸盐大于SO34-大于IO-3大于F-大于BrO-3大于醋酸盐。在物理化学上，易化阴离子属于“水结构形成离子”类，而抑制阴离子则属于“水结构破坏离子”类。当氯离子浓度低于60 mM时，SO34-减弱了氯离子的抑制作用，当浓度大于60 mM时，则增强了氯离子的抑制作用。Na+和Li+对水单位活性无明显影响，K+对水单位活性的刺激作用较弱。结果表明，阴离子通过膜的外流刺激水受体，而阴离子的内流则抑制水受体，SO34-促进氯离子的通透性。从离子周围的水结构与受体膜相互作用的角度，讨论了SO24-促进氯离子渗透的机理。
The effects of various ions on water response was studied by recording unitary discharges in single superior laryngeal nerve fibers of the rabbit. The water response was strongly influenced by anions. The inorganic anions used were divided into two groups. One group consisted of anions which depress the water response (depressing anions), the depressing action sequence being SCN- greater than Br- greater than than Cl- greater than I- greater than NO-3. Another one consisted of anions which facilitate the water response (facilitating anions), the facilitating action sequence being citrate greater than SO34- greater than IO-3 greater than F- greater than BrO-3 greater than acetate. Physicochemically, facilitating anions belong to "the water structure-making ions" group; on the other hand, depressing anions belong to "the water structure-breaking ions" group. SO34- weakened the depressing effect of Cl- when the concentration of Cl- was below 60 mM, and enhanced it when the concentration was above 60 mM. Na+ and Li+ had no appreciable effect on the water unit activity, but K+ had a weakly stimulating effect. It is concluded that an outflux of anions through the membrane stimulates the water receptor while an influx of anions depresses it, and SO34- facilitates Cl- permeability. The mechanism of the facilitating effect of SO24- on Cl- permeation is discussed in terms of the interaction between the water structure surrounding the ions and the receptor membrane.