Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease.
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease.
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DOI：
10.1002/hep.23535
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发表时间：
2010-06
期刊：
影响因子：
13.5
通讯作者：
Diehl, Anna Mae
中科院分区：
文献类型：
--
作者：
Abdelmalek, Manal F.;Suzuki, Ayako;Guy, Cynthia;Unalp-Arida, Aynur;Colvin, Ryan;Johnson, Richard J.;Diehl, Anna Mae
肥胖和糖尿病发病率的上升与果糖消费量的显著增加相吻合。非酒精性脂肪性肝病（NAFLD）患者的果糖消耗量高于年龄和BMI匹配的对照组。由于果糖会引起可能具有肝毒性的代谢紊乱，我们研究了果糖摄入量与NAFLD疾病严重程度之间的关系。我们研究了341名参加NASH临床研究网络的成年人，他们在肝活检后3个月内收集了块状食物问卷数据。果糖的摄入量是根据Kool-aid，果汁和非膳食苏打水摄入量的报告（频率×数量）估计的，以每周的份数表示，并分为无，偶尔（< 7份/周）和每日（> = 7份/周）。果糖摄入与NAFLD代谢和组织学特征的相关性在控制和不控制其他混杂因素的情况下使用多元线性和逻辑回归分析进行分析。果糖摄入量增加与年龄降低（p < 0.0001）、男性（p < 0.0001）、高甘油三酯血症（p < 0.04）、低HDL胆固醇（p < 0.0001）、血清葡萄糖降低（p < 0.001）、卡路里摄入量增加（p < 0.0001）和高尿酸血症（p < 0.0001）呈单变量相关。在控制了年龄、性别、BMI和总热量摄入后，每日果糖摄入量与较低的脂肪变性分级和较高的纤维化分期相关（各P < 0.05）。在老年人（年龄> 48岁）中，每日果糖摄入量与肝脏炎症增加（p < 0.05）和肝细胞气球样变（p = 0.05）相关。在NAFLD患者中，每日摄入果糖与肝脂肪变性减少但纤维化增加相关。这些结果确定了一个容易改变的环境风险因素，可以改善NAFLD患者的疾病进展。
The rising incidence of obesity and diabetes coincides with a marked increase in fructose consumption. Fructose consumption is higher in individuals with nonalcoholic fatty liver disease (NAFLD) than age- and BMI-matched controls. Because fructose elicits metabolic perturbations that may be hepatotoxic, we investigated the relationship between fructose consumption and disease severity in NAFLD. We studied 341 adults enrolled in the NASH Clinical Research Network for whom Block food questionnaire data were collected within 3 months of a liver biopsy. Fructose consumption was estimated based on reporting (frequency × amount) of kool-aid, fruit juices, and non-dietary soda intake, expressed as servings per week, and classified into none, occasional (< 7 servings/week), and daily (> = 7 servings/week). The association of fructose intake with metabolic and histologic features of NAFLD was analyzed using multiple linear and logistic regression analyses with and without controlling for other confounding factors. Increased fructose consumption was univariately associated with decreased age (p < 0.0001), male gender (p < 0.0001), hypertriglyceridemia (p < 0.04), low HDL cholesterol (< 0.0001), decreased serum glucose (p < 0.001), increased calorie intake (p < 0.0001) and hyperuricemia (p < 0.0001). After controlling for age, gender, BMI, and total calorie intake, daily fructose consumption was associated with lower steatosis grade and higher fibrosis stage (p < 0.05 for each). In older adults (age > 48 years), daily fructose consumption was associated with increased hepatic inflammation (p < 0.05) and hepatocyte ballooning (p = 0.05). In patients with NAFLD, daily fructose ingestion is associated with reduced hepatic steatosis but increased fibrosis. These results identify a readily modifiable environmental risk factor that may ameliorate disease progression in patients with NAFLD.
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影响因子：
9.8
作者：
Fargion, S;Mattioli, M;Fiorelli, G
通讯作者：
Fiorelli, G
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
影响因子：
5.1
作者：
Caldwell, Stephen H;Chang, Charissa Y;Krugner-Higby, Lisa
通讯作者：
Krugner-Higby, Lisa
影响因子：
2.2
作者：
Chalasani NP;Sanyal AJ;Kowdley KV;Robuck PR;Hoofnagle J;Kleiner DE;Unalp A;Tonascia J;NASH CRN Research Group
通讯作者：
NASH CRN Research Group
影响因子：
4.5
作者：
Basciano, Heather;Federico, Lisa;Adeli, Khosrow
通讯作者：
Adeli, Khosrow