Immunopathology alters Th17 cell glucocorticoid sensitivity.
Immunopathology alters Th17 cell glucocorticoid sensitivity.
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作者：
Banuelos J;Cao Y;Shin SC;Lu NZ
Th17细胞参与了几种炎症状态，越来越多的证据支持Th17细胞对糖皮质激素具有抵抗力。然而，银屑病及相关疾病中的Th17细胞对糖皮质激素敏感。我们比较了糖皮质激素敏感型和抵抗型免疫性疾病，并认为Th-17相关疾病的几个方面改变了Th17细胞的糖皮质激素敏感性。我们在文献中确定了与Th17细胞对糖皮质激素敏感性有关的分子途径，因为这些信息有助于开发克服糖皮质激素耐药免疫病理学的方法。
Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th-17 related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.