Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway.
Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway.
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DOI：
10.1038/s41598-021-85936-6
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发表时间：
2021-03-22
影响因子：
4.6
通讯作者：
Westenberg JJM
中科院分区：
文献类型：
--
作者：
Rijnberg FM;van Assen HC;Juffermans JF;Kroft LJM;van den Boogaard PJ;de Koning PJH;Hazekamp MG;van der Woude SFS;Warmerdam EG;Leiner T;Grotenhuis HB;Goeman JJ;Lamb HJ;Roest AAW;Westenberg JJM
较长的扫描时间限制了4D Flow MRI在Fontan患者中的广泛临床适用性。由于心动周期中Fontan通路的脉动性很小，与2D和4D Flow MRI相比，获得非心电门控3D Flow MRI可以减少扫描时间，同时准确地获得时间平均的临床参数。32例Fontan患者前瞻性地接受了Fontan通路的2D(参考)、3D和4D Flow MRI检查。根据时间平均血流速度评估多个临床参数，包括从右到左的肺血流分布(主要终点)和体肺侧支血流(SPCF)。扫描时间缩短10倍[4D Flow 15.9min(SD 2.7min)，3D Flow 1.6min(SD 7.8；S)，p <； 0.001]，信噪比[Mean SNR1.7(0.8)，p <； 0.001]和血管清晰度[Mean Ratio 1.2(0.4)，p = 0.01]。与2D血流相比，平均血流速度(ICC0.82~0.96)和从右向左肺血流分布(ICC0.97)具有良好的一致性。3D血流与4D血流的SPCF具有较好的一致性(ICC0.86)。3D Flow MRI可以获得Fontan通路中的时间平均流速和衍生的临床参数，与2D和4D Flow非常吻合，但与4D Flow相比，扫描时间减少了10倍，图像质量显著改善。
Long scan times prohibit a widespread clinical applicability of 4D flow MRI in Fontan patients. As pulsatility in the Fontan pathway is minimal during the cardiac cycle, acquiring non-ECG gated 3D flow MRI may result in a reduction of scan time while accurately obtaining time-averaged clinical parameters in comparison with 2D and 4D flow MRI. Thirty-two Fontan patients prospectively underwent 2D (reference), 3D and 4D flow MRI of the Fontan pathway. Multiple clinical parameters were assessed from time-averaged flow rates, including the right-to-left pulmonary flow distribution (main endpoint) and systemic-to-pulmonary collateral flow (SPCF). A ten-fold reduction in scan time was achieved [4D flow 15.9 min (SD 2.7 min) and 3D flow 1.6 min (SD 7.8 s), p < 0.001] with a superior signal-to-noise ratio [mean ratio of SNRs 1.7 (0.8), p < 0.001] and vessel sharpness [mean ratio 1.2 (0.4), p = 0.01] with 3D flow. Compared to 2D flow, good–excellent agreement was shown for mean flow rates (ICC 0.82–0.96) and right-to-left pulmonary flow distribution (ICC 0.97). SPCF derived from 3D flow showed good agreement with that from 4D flow (ICC 0.86). 3D flow MRI allows for obtaining time-averaged flow rates and derived clinical parameters in the Fontan pathway with good–excellent agreement with 2D and 4D flow, but with a tenfold reduction in scan time and significantly improved image quality compared to 4D flow.
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影响因子：
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