Reactive oxygen species drives myocardial angiogenesis?
Reactive oxygen species drives myocardial angiogenesis?
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DOI：
10.1089/ars.2006.8.2161
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发表时间：
2006-11-01
影响因子：
6.6
通讯作者：
Maulik, Nilanjana
中科院分区：
文献类型：
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作者：
Maulik, Nilanjana
新血管形成是新血管形成的自然生理过程，对于改善缺血性应激心脏的功能极为重要。这个过程对于治疗缺血性心脏和肢体疾病（包括毛细血管（血管生成）和侧支动脉的形成）可能很重要。缺血或冠状动脉闭塞在实验性大鼠心肌梗死模型中诱导血管内皮生长因子（VEGF），并且该分子促进冠状动脉侧支循环的发展和缺血区域的血液供应的保持。缺血区域血液供应的恢复防止心肌细胞死亡和心脏重塑。在血管生成的各种触发剂和增强剂中，缺氧或缺血预处理以及药理学试剂如他汀类和白藜芦醇已被确定为诱导新血管生长的重要刺激物。已经证明VEGF家族及其受体系统是血管生成的氧化还原细胞信号传导中的基本调节剂。本文就活性氧在心肌血管生成过程中的作用作一综述。
Neovascularization, the natural physiological process of formation of new blood vessels, is extremely important for ameliorating the function of the heart that undergoes ischemic stress. This process is potentially important for the treatment of ischemic heart and limb diseases, which includes formation of capillaries (angiogenesis) and collateral arteries. Ischemia or coronary artery occlusion induces vascular endothelial growth factor (VEGF) in the experimental rat myocardial infarction model, and this molecule encourages development of coronary collateral circulation and retention of the blood supply to the ischemic area. Restoration of the blood supply to the ischemic area prevents cardiomyocyte death and cardiac remodeling. Among the various triggers and enhancers of angiogenesis, hypoxic or ischemic preconditioning, as well as pharmacologic agents such as statin and resveratrol, have been identified as important stimuli for the induction of new vessel growth. It has already been demonstrated that the VEGF family and its receptor system is the fundamental regulator in the redox cell signaling of angiogenesis. This review article will focus on the role of reactive oxygen species in the process of myocardial angiogenesis.