Normative equations for central augmentation index: assessment of inter-population applicability and how it could be improved.
Normative equations for central augmentation index: assessment of inter-population applicability and how it could be improved.
复制标题
中央增强指数的规范方程：评估人口间的适用性及其如何改善。
DOI：
10.1038/srep27016
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发表时间：
2016-05-27
影响因子：
4.6
通讯作者：
Boban M
中科院分区：
文献类型：
--
作者：
Jeroncic A;Gunjaca G;Mrsic DB;Mudnic I;Brizic I;Polasek O;Boban M
动脉硬度指标的共同参考值可作为检测危险血管表型的有效筛选工具。然而，由于不同的环境压力，同一种族的人群在血管表型上可能存在差异。我们检验了从低心血管风险的丹麦人群中得出的中心增强指数（cAIx）的规范性方程对相应的地中海地区克罗地亚人群的适用性。通过Bland-Altman分析评估实测和预测cAIx之间的差异。克罗地亚数据的caix年龄分布和规范性方程与丹麦低风险样本具有高度可比性。相反，Bland-Altman对cAIx不一致的分析显示了与完全一致线的曲线偏差，这表明方程在不同年龄范围内并不同样适用。将个人数据按年龄分层，消除了除30-39岁（男性）和40-49岁（女性）以外的所有年龄段的曲线性。在其他几十年里，独立于年龄的线性分歧持续存在，这表明除了年龄之外的cAIx决定因素没有被设想/被提议的方程补偿。因此，既定的规范方程式同样适用于北欧和地中海人口，但用途有限。如果设计用于更窄的年龄范围，则方程在检测危险血管表型方面的敏感性和对不同人群的适用性可以得到提高。
Common reference values of arterial stiffness indices could be effective screening tool in detecting vascular phenotypes at risk. However, populations of the same ethnicity may differ in vascular phenotype due to different environmental pressure. We examined applicability of normative equations for central augmentation index (cAIx) derived from Danish population with low cardiovascular risk on the corresponding Croatian population from the Mediterranean area. Disagreement between measured and predicted cAIx was assessed by Bland-Altman analysis. Both, cAIx-age distribution and normative equation fitted on Croatian data were highly comparable to Danish low-risk sample. Contrarily, Bland-Altman analysis of cAIx disagreement revealed a curvilinear deviation from the line of full agreement indicating that the equations were not equally applicable across age ranges. Stratification of individual data into age decades eliminated curvilinearity in all but the 30–39 (men) and 40–49 (women) decades. In other decades, linear disagreement independent of age persisted indicating that cAIx determinants other than age were not envisaged/compensated for by proposed equations. Therefore, established normative equations are equally applicable to both Nordic and Mediterranean populations but are of limited use. If designed for narrower age ranges, the equations’ sensitivity in detecting vascular phenotypes at risk and applicability to different populations could be improved.