A Histological and Immunohistochemical Study of Medical‐Grade Fluid Silicone
A Histological and Immunohistochemical Study of Medical‐Grade Fluid Silicone
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医用级流体硅胶的组织学和免疫组织化学研究
DOI：
10.1111/j.1524-4725.1998.tb04264.x
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发表时间：
1998
影响因子：
2.4
通讯作者：
A. Perissios
中科院分区：
文献类型：
--
作者：
D. Dasiou;K. Pantelidaki;C. Dara;D. Chrisanthakis;A. Perissios
背景用于软组织填充的医用级可注射硅胶通过注射纯材料进行皮下给药。objective.旨在从组织学和电化学角度检查医用级硅胶的特性，并确定连续穿刺技术的优缺点。结果在早期活检中，观察到血管周围淋巴细胞浸润伴迟发型超敏反应（剂量，0.05 - 0.07 mL）的特征性反应。免疫组化显示，在小血管壁周围观察到IgG和IgA的小局部沉积。在后来的活检中，炎症进展为成纤维细胞反应。此外，植入大剂量引起巨细胞肉芽肿。结论.小剂量（0.05 - 0.07 mL）注射硅胶会在皮肤中产生免疫和成纤维细胞反应。当使用适当的技术时，该物质与连续穿刺技术一起使用没有危险。
background. Medical‐grade injectable silicone for use in soft tissue augmentation is administered subcutaneousty by injections of the pure material. objective. To examine histologically and immunohistochemi‐cally the characteristics of medical‐grade silicone and to identify the advantages and disadvantages of the serial puncture technique. results. In early biopsies, perivascular lymphocytic infiltration with the characteristic reaction of delayed hypersensitivity (doses, 0.05–0.07 mL) was observed. Immunohistochemically, small local deposits of lgG and IgA were observed around the walls of small vessels. In later biopsies, the inflammation had progressed to a fibroblastic reaction. Additionally, the implantation of large doses provoked giant cell granulomas. conclusions. Small doses (0.05–0.07 mL) of injected silicone produce an immunologic and fibroblastic reaction in the skin. The use of this substance with the serial puncture technique is not hazardous when proper technique is used.