A Particle Dynamic Model of Red Blood Cell Aggregation Kinetics
A Particle Dynamic Model of Red Blood Cell Aggregation Kinetics
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DOI：
10.1007/s10439-009-9775-1
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发表时间：
2009-11-01
影响因子：
3.8
通讯作者：
Cloutier, Guy
中科院分区：
文献类型：
--
作者：
Fenech, Marianne;Garcia, Damien;Cloutier, Guy
为了阐明微观红细胞（RBC）之间的相互作用和宏观流变行为的关系，我们提出了一个二维粒子模型，能够模仿的主要特征的红细胞聚集动力学。红细胞在库埃特流中剪切的力学模型是基于牛顿定律。我们假设一个流体动力来移动粒子，一个力来描述聚集和弹性力。中性聚合物的分子量和浓度对聚集的作用[Neu，B.，和H. J·梅塞尔曼Biophys. J. 83：2482-2490，2002]可以被模仿。具体而言，结果表明，对于任何剪切速率（SR），平均聚集体尺寸（MAS）随时间增长，直到达到一个恒定值，这与体外实验一致。同时也证明了我们可以模拟MAS和SR之间的模态关系以及在0.1s（-1）左右出现的最大聚集。正如预期的那样，模拟表明，聚合力的增加增强了MAS。此外，耗尽层厚度的增加仅对SR接近于零的MAS产生影响，这是一个新的发现。总之，我们的贡献表明，聚集力强度和SR影响稳态MAS，耗尽和层厚度影响聚集速度。
To elucidate the relationship between microscopic red blood cell (RBC) interactions and macroscopic rheological behavior, we propose a two-dimensional particle model capable of mimicking the main characteristics of RBC aggregation kinetics. The mechanical model of RBCs sheared in Couette flow is based on Newton law. We assumed a hydrodynamic force to move particles, a force to describe aggregation and an elasticity force. The role of molecular mass and concentration of neutral polymers on aggregation [Neu, B., and H. J. Meiselman. Biophys. J. 83: 2482-2490, 2002] could be mimicked. Specifically, it was shown that for any shear rate (SR), the mean aggregate size (MAS) grew with time until it reached a constant value, which is consistent with in vitro experiments. It was also demonstrated that we could mimic the modal relationship between MAS and SR and the occurrence of maximum aggregation at about 0.1 s(-1). As anticipated, simulations indicated that an increase in aggregation force augmented MAS. Further, augmentation of the depletion layer thickness influenced MAS only for SR close to zero, which is a new finding. To conclude, our contribution reveals that the aggregation force intensity and SR influence the steady state MAS, and that the depletion and layer thickness affect the aggregation speed.