Commissural axonal corridors instruct neuronal migration in the mouse spinal cord
Commissural axonal corridors instruct neuronal migration in the mouse spinal cord
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DOI：
10.1038/ncomms8028
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发表时间：
2015-05-01
影响因子：
16.6
通讯作者：
Wilson, Sara I.
中科院分区：
文献类型：
--
作者：
Laumonnerie, Christophe;Tong, Yong Guang;Wilson, Sara I.
揭示在脊椎动物胚胎发育过程中神经元是如何被引导的，对于理解神经系统的组装具有广泛的意义。在胚胎发生过程中，神经元细胞体和轴突的迁移是同时发生的，但它们在多大程度上相互影响发育尚不清楚。我们在这里表明，在小鼠胚胎脊髓内，共交轴突平分、划分或预先配置腹侧中间神经元细胞体位置。此外，互交轴突的遗传破坏导致腹侧神经元中间细胞体定位异常。这些数据表明，交联轴突束通过作为边界标志（轴突限制迁移）或作为细胞向导来指导细胞体位置，据我们所知，这在以前还没有解决过。这项在发育中的脊髓的研究强调了细胞体和轴突相互作用的重要功能，并提供了一个概念上的原理证明，这可能对神经元结构的发展具有总体意义。
Unravelling how neurons are guided during vertebrate embryonic development has wide implications for understanding the assembly of the nervous system. During embryogenesis, migration of neuronal cell bodies and axons occurs simultaneously, but to what degree they influence each other's development remains obscure. We show here that within the mouse embryonic spinal cord, commissural axons bisect, delimit or preconfigure ventral interneuron cell body position. Furthermore, genetic disruption of commissural axons results in abnormal ventral interneuron cell body positioning. These data suggest that commissural axonal fascicles instruct cell body position by acting either as border landmarks (axon-restricted migration), which to our knowledge has not been previously addressed, or acting as cellular guides. This study in the developing spinal cord highlights an important function for the interaction of cell bodies and axons, and provides a conceptual proof of principle that is likely to have overarching implications for the development of neuronal architecture.