High-resolution technetium-99m-HMPAO SPECT in patients with probable Alzheimer's disease: comparison with fluorine-18-FDG PET.
High-resolution technetium-99m-HMPAO SPECT in patients with probable Alzheimer's disease: comparison with fluorine-18-FDG PET.
复制标题
疑似阿尔茨海默病患者的高分辨率 technetium-99m-HMPAO SPECT：与氟 18-FDG PET 的比较。
作者：
C. Messa;D. Perani;G. Lucignani;A. Zenorini;Felicia Zito;Giovanna Rizzo;F. Grassi;A. Sole;Massimo Franceschi;M. Gilardi;F. Fazio
未标记
在21例可能患有阿尔茨海默病（AD）的患者中，将高分辨率系统的局部脑灌注SPECT研究与局部脑葡萄糖利用（rCMRglc）的PET研究进行了比较。10名正常人也进行了评价与SPECT和10与PET。
方法
将联合皮质中的rCMRglc（用于PET）和计数（用于SPECT）标准化为平均rCMRglc，并将距状皮质和基底神经节中的计数视为“参考区域”以获得比值。分别对PET和SPECT进行方差分析，检验患者和对照组之间的比值差异。
结果
在PET（p < 0.00001）和SPECT（p < 0.005）中，可能的AD患者和对照组之间的差异都是显著的; PET的额叶、颞叶和顶叶皮质（p < 0.0001）以及SPECT的颞叶（p < 0.005）和顶叶（p < 0.001）皮质的差异都是显著的。在所有受试者中，PET和SPECT均检测到颞顶叶缺陷，占90%。
结论
PET和SPECT能够检测可能AD的特征性颞顶异常。然而，在其他相关领域的异常的存在更好地评价与PET。
UNLABELLED
SPECT studies of regional cerebral perfusion with a high-resolution system were compared to PET studies of regional cerebral glucose utilization (rCMRglc) in 21 patients with probable Alzheimer's disease (AD). Ten normal subjects were also evaluated with SPECT and 10 with PET.
METHODS
rCMRglc (for PET) and counts (for SPECT) in the associative cortices were normalized to the average rCMRglc, and counts in the calcarine cortex and basal ganglia were considered as a "reference area" to obtain a ratio. The ratio differences between patients and controls were tested with ANOVA performed separately for PET and SPECT.
RESULTS
The difference between probable AD patients and controls was significant for both PET (p < 0.00001) and SPECT (p < 0.005); this difference was significant for the frontal, temporal and parietal cortices (p < 0.0001) for PET, and for the temporal (p < 0.005) and parietal (p < 0.001) cortices for SPECT. Temporo-parietal defects were detected in all subjects with PET and in 90% with SPECT.
CONCLUSION
PET and SPECT are able to detect characteristic temporo-parietal abnormalities in probable AD. However, the presence of abnormalities in other associative areas is better evaluated with PET.