Comparison of Cartilage Mechanical Properties Measured During Creep and Recovery
Comparison of Cartilage Mechanical Properties Measured During Creep and Recovery
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DOI：
10.1038/s41598-020-58220-2
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发表时间：
2020-01-31
影响因子：
4.6
通讯作者：
DeFrate, Louis E.
中科院分区：
文献类型：
--
作者：
Cutcliffe, Hattie C.;DeFrate, Louis E.
目前，骨关节炎（OA）的诊断取决于疼痛的存在和放射学成像结果，这些结果通常要到疾病后期才出现，此时病情难以治疗。因此，需要早期检测OA病理以改善疾病管理。离体软骨研究表明，在OA期间，随着退行性变的进展，软骨的机械功能发生变化。因此，体内软骨机械反应的测量可以作为OA病理学的早期指标。虽然机械表征通常在加载期间进行，但软骨的卸载（恢复）响应也可以使得能够确定机械响应。因此，本研究的目的是验证在受控的离体环境中使用恢复响应进行软骨的机械表征。为此，对软骨外植体（N = 10）进行了有限压缩蠕变和恢复试验，并比较了蠕变和恢复阶段所得的机械性能。两个阶段之间的机械性能没有统计学显著差异，加强了卸载（恢复）可能是加载的良好替代的假设。
The diagnosis of osteoarthritis (OA) currently depends on the presence of pain and radiographic imaging findings, which generally do not present until later stages of the disease when the condition is difficult to treat. Therefore, earlier detection of OA pathology is needed for improved disease management. Ex vivo cartilage studies indicate that changes in the mechanical function of cartilage occur as degeneration progresses during OA. Thus, measurement of the in vivo cartilage mechanical response may serve as an earlier indicator of OA pathology. Though mechanical characterization is classically performed during loading, the unloading (recovery) response of cartilage may also enable determination of mechanical response. Therefore, the purpose of this study was to validate the use of the recovery response for mechanical characterization of cartilage in a controlled, ex vivo environment. To do so, confined compression creep and recovery tests were conducted on cartilage explants (N = 10), and the resulting mechanical properties from both the creep and recovery phases were compared. No statistically significant differences were found in the mechanical properties between the two phases, reinforcing the hypothesis that unloading (recovery) may be a good surrogate for loading.