Is there a true requirement for follicle stimulating hormone in promoting spermatogenesis and fertility in primates?
Is there a true requirement for follicle stimulating hormone in promoting spermatogenesis and fertility in primates?
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DOI：
10.1093/humrep/13.4.916
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发表时间：
1998-04-01
影响因子：
6.1
通讯作者：
Sairam, MR
中科院分区：
文献类型：
--
作者：
Moudgal, NR;Sairam, MR
尽管促卵泡激素（FSH）在调节卵巢功能中的作用已被广泛接受，但其在调节成人睾丸功能中的作用仍然存在争议，所有哺乳动物的支持细胞都具有 FSH 受体，并且已知可调节生殖细胞向精子的分化和转化。然而，FSH 调节精子发生的方式似乎存在物种和年龄差异。本文试图批判性地审查支持和反对 FSH 调节灵长类动物精子发生和生育能力这一概念的可用新数据。由于没有证据表明猴子和人类的睾丸功能受到不同的调节，因此使用猴子作为实验替代模型进行了深入讨论。只要可行，这些都与临床研究中出现的新信息相关。从这些研究看来，在灵长类动物（包括人类）中，FSH除了促进定量精子发生从而产生正常数量的精子外，在调节精子发生（控制正常可受精的成熟精子形成的过程）方面也具有关键作用。虽然在雄性猴子中对FSH促进生育力的要求已经相当明确，但在人类中，目前支持这一概念的证据仍然是间接的，需要做更多的工作来毫无疑问地建立这一假设。
Although the role of follicle stimulating hormone (FSH) in regulating ovarian function is well accepted, its need in regulating testicular function of the adult continues to be debated, Sertoli cells of all mammals have FSH receptors and are known to regulate differentiation and transformation of germ cells to spermatozoa. However, there appear to be species and age differences in the way in which FSH regulates spermatogenesis, An attempt has been made in the current paper to examine critically the newer data available in support of and against the concept that FSH is required to regulate spermatogenesis and fertility of the primate, As there is no evidence to indicate that testicular function in monkeys and humans is regulated differently the information available using the monkey as the experimental surrogate model is discussed in some depth. These are correlated, wherever feasible, to the newer information emerging from clinical studies. It appears from these studies that in the primate (including humans) FSH, besides promoting quantitative spermatogenesis leading to production of a normal number of spermatozoa, has a critical role in regulating spermiogenesis, the process that controls the formation of normal fertilizable mature spermatozoa, While the requirement for FSH in promoting fertility in the male monkey is reasonably well established, in humans the evidence currently available in favour of the concept is still circumstantial and more work needs to be done to establish the hypothesis beyond any doubt.