Clinical Correlates of Reduced Physical Activity in Idiopathic Pulmonary Fibrosis-猫眼课题宝

DOI：

10.1159/000446607

发表时间：

2016-01-01

期刊：

RESPIRATION

影响因子：

3.7

通讯作者：

中科院分区：

医学3区

文献类型：

作者：

Bahmer, Thomas;Kirsten, Anne-Marie;Watz, Henrik

背景：特发性肺纤维化(IPF)对体力活动(PA)的影响目前知之甚少。目的：研究特发性肺纤维化患者血浆PA水平及其与肺功能、运动能力、症状和生活质量的关系。方法：对缓解期IPF患者采用SenseWear臂章加速仪测定PA(每日步行数，SPD；体力活动水平，PAL；中等活动分钟数，MMA)，共1周。我们还评估了肺功能(用力肺活量，FVC；一氧化碳弥散量，DLCO)；运动能力(6分钟步行距离，6MWD)；呼吸困难(改良医学研究委员会，MMRC)；疲劳(多维疲劳量表，MFI-20)，通用(12项简表调查，SF-12)和与健康相关的生活质量(圣乔治呼吸问卷)作为进一步的临床变量。结果：我们调查了两个中心的48例IPF患者(平均年龄67岁；男性占75%；接受长期氧疗的患者占23%；平均FVC占75%；平均DLCO占43%；平均6MWD355+/-140m；平均SPD5017+/-3360)。在双变量水平上，所有临床变量与SPD显著相关(p&lt；0.05)。MMRC、MFI-20、SF-12(身体健康)和6MWD与SPD的相关性与肺功能受损无关(p&lt；0.05)。在多变量分析中，6MWD(模型的总解释方差，总R-2：42%)或MFI-20(总R-2：39%)是预测SPD的最强独立因素。结论：疲劳和运动能力是IPF患者PA的独立预测因子，应在研究IPF对日常生活中PA的影响时对这两项指标进行评估。(C)2016年S.Karger AG，巴塞尔

Background: Little is known about the consequences of idiopathic pulmonary fibrosis (IPF) for physical activity (PA). Objectives: We aimed to investigate levels of PA in IPF and to study associations of PA with lung function, exercise capacity, symptoms, and quality of life. Methods: In stable patients with IPF we measured PA (steps per day, SPD; physical activity level, PAL; minutes of moderate activity, MMA) by accelerometry (SenseWear Armband) for 1 week. We also assessed lung function (forced vital capacity, FVC; diffusing capacity for carbon monoxide, DLCO); exercise capacity (6-minute walking distance, 6MWD); dyspnea (modified Medical Research Council, mMRC); fatigue (Multidimensional Fatigue Inventory, MFI-20), and generic (12-Item Short Form Survey, SF-12) and health-related quality of life (St. George's Respiratory Questionnaire) as further clinical variables. Results: We investigated 48 patients with IPF in two centers (mean age, 67 years; 75% male; 23% on long-term oxygen therapy; mean FVC 75%pred.; mean DLCO 43%pred.; mean 6MWD 355 +/- 140 m; mean SPD 5,017 +/- 3,360). On a bivariate level, all clinical variables were significantly associated with SPD (p < 0.05). The associations of mMRC, MFI-20, SF-12 (physical health), and 6MWD with SPD were independent of impaired lung function (p < 0.05). At multivariate analyses, either 6MWD (total explained variance of the model, total R-2: 42%) or MFI-20 (total R-2: 39%) were the strongest independent predictors of SPD. Conclusion: Fatigue and exercise capacity are strong and independent predictors of PA in patients with IPF, which suggests that both measures should be assessed when the consequences of IPF for PA in daily life are studied. (C) 2016 S. Karger AG, Basel

Clinical Correlates of Reduced Physical Activity in Idiopathic Pulmonary Fibrosis

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