1D and 2D error assessment and correction for extrusion-based bioprinting using process sensing and control strategies
1D and 2D error assessment and correction for extrusion-based bioprinting using process sensing and control strategies
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DOI：
10.1088/1758-5090/aba8ee
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发表时间：
2020-10-01
期刊：
影响因子：
9
通讯作者：
Johnson, Amy J. Wagoner
中科院分区：
文献类型：
--
作者：
Armstrong, Ashley A.;Alleyne, Andrew G.;Johnson, Amy J. Wagoner
生物打印文献目前缺乏：（i）测量材料沉积的过程传感工具，（ii）评估系统性能的性能指标，以及（iii）纠正和避免材料沉积错误的控制工具。过程传感工具的缺乏限制了生物打印部件的体内功能，因为准确的材料沉积对于模仿天然组织的异质结构至关重要。我们提出了一种基于挤出的制造的过程监控和控制策略，该策略解决了所有三个差距，以改善材料沉积。我们的策略使用非接触式激光位移扫描仪来测量空间材料放置和沉积材料的宽度。我们开发了一个自定义图像处理脚本，该脚本使用激光扫描仪数据和定义的误差指标来评估材料沉积。为了实现过程控制，该脚本使用错误度量来修改下一次沉积迭代的控制输入，以纠正错误。一个关键贡献是定义了一种定量评估印刷结构准确性的新方法。我们在挤出印刷系统上实施过程监控策略，以评估系统性能并展示材料放置和材料宽度方面的改进。
The bioprinting literature currently lacks: (i) process sensing tools to measure material deposition, (ii) performance metrics to evaluate system performance, and (iii) control tools to correct for and avoid material deposition errors. The lack of process sensing tools limitsin vivofunctionality of bioprinted parts since accurate material deposition is critical to mimicking the heterogeneous structures of native tissues. We present a process monitoring and control strategy for extrusion-based fabrication that addresses all three gaps to improve material deposition. Our strategy uses a non-contact laser displacement scanner that measures both the spatial material placement and width of the deposited material. We developed a custom image processing script that uses the laser scanner data and defined error metrics for assessing material deposition. To implement process control, the script uses the error metrics to modify control inputs for the next deposition iteration in order to correct for the errors. A key contribution is the definition of a novel method to quantitatively evaluate the accuracy of printed constructs. We implement the process monitoring and control strategy on an extrusion-printing system to evaluate system performance and demonstrate improvement in both material placement and material width.