Effect of the porcine IGF2-intron3-G3072A substitution in an outbred Large White population and in an Iberian x Landrace cross.
Effect of the porcine IGF2-intron3-G3072A substitution in an outbred Large White population and in an Iberian x Landrace cross.
复制标题
DOI：
10.2527/2005.83122723x
复制
发表时间：
2005-12
影响因子：
3.3
通讯作者：
J. Estellé;A. Mercadé;J. Noguera;M. Pérez-Enciso;C. Óvilo;A. Sánchez;J. Folch
中科院分区：
文献类型：
--
作者：
J. Estellé;A. Mercadé;J. Noguera;M. Pérez-Enciso;C. Óvilo;A. Sánchez;J. Folch
IGF2内含子3- g3072a取代最近被描述为在猪IGF2区域检测到的脂肪沉积和肌肉生长的印迹QTL的原因。本研究的目的是研究IGF2在大型白种人远交种群体和伊比利亚与长白种F2杂交中的替代效应。结果表明，替代对肥度、生长和形状性状有显著影响，且影响方向与预期方向一致。这些结果与F2杂交中获得的结果一致，其中IGF2-intron3-G3072A替代仅在一个小家族中分离。此外，在F2群体中对用于IGF2替代效应验证的性状进行了QTL扫描。本研究结果表明，猪2号染色体除IGF2替代外，还存在QTL分离，在屠宰后24 h测量胴体重、LM面积和pH。结果证实了IGF2替代的相关性，但他们也表明，在这条染色体上仍有有价值的突变有待揭示。
The IGF2-intron3-G3072A substitution has been recently described as the causal factor of the imprinted QTL for fat deposition and muscle growth detected within the porcine IGF2 region. The objective of this study was to investigate the IGF2 substitution effect in a Large White outbred population and in an Iberian x Landrace F2 cross. The results showed that the substitution has significant effects on fatness, growth, and shape traits with estimated effects in the expected direction. These results agree with those obtained in the F2 cross, where the IGF2-intron3-G3072A substitution is segregating only in a small family. In addition, a QTL scan has been performed in the F2 population for the traits used in the IGF2 substitution effect validation. Results of this study demonstrated that there are QTL segregating in swine chromosome 2 other than the IGF2 substitution for carcass weight, LM area, and pH measured at 24 h after slaughter. The results confirm the relevance of the IGF2 substitution, but they also show that there are still valuable mutations to be revealed in this chromosome.