Projections to the median eminence and the arcuate nucleus with special reference to monoamine systems: Effects of lesions
Projections to the median eminence and the arcuate nucleus with special reference to monoamine systems: Effects of lesions
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对正中隆起和弓状核的投影，特别参考单胺系统：病变的影响
DOI：
10.1007/bf00219949
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发表时间：
2004
影响因子：
3.6
通讯作者：
T. Hökfelt
中科院分区：
文献类型：
--
作者：
K. Ajika;T. Hökfelt
用Halász刀进行了不同类型的下丘脑去传入实验，用Falck-Hillarp技术和乙醛-OsO_4或KMnO_4固定材料的电子显微镜对雄性大鼠正中隆起外层和弓状核进行了研究。结果如下：1.经背侧入路，ELME的主要单胺能输入来自弓状核-脑室周围区。水平切断弓状核可减少单胺类突触和小颗粒囊泡的百分比，从对照组的31.6%减少到损伤组的4.4%，而在前部(或完全)去传入后仅见轻微影响。2.ELME的主要输入在前外侧进入下丘脑基础部位(见Réthelyi和Halász，1970)。前去传入后切断的神经纤维很可能主要来自下丘脑前部或更远端的细胞体，但也有一些可能代表从下脑干升起的NA轴突。3.前去传入后和弓状核损伤后，Elme内神经末梢的退化过程迅速(2-3天内)，形态特征是最初聚集的大而致密的核心小泡似乎是外周内的电子致密体，可能也是小的电子通透性突触小泡(见Raisman，1972)。这种类型的变性似乎既发生在单胺神经元中，也发生在非单胺神经元中。4.在前部和完全去传入后，弓状核出现退行性变。因此，下丘脑前部可能通过对弓状神经元的突触“间接”控制垂体腺，但通过向Elme投射的“直接”影响在数量上更为重要。5.在前部去传入后，在切口处的尾部发现了含有大量致密的核心囊泡和其他细胞器的扩大的轴突，这表明存在来自下丘脑内侧的吻部投射。这些结果已部分报道于1974年4月8-10日在东京举行的第47届日本内分泌学会年会。
The external layer of the median eminence (ELME) and the arcuate nucleus of male rats were studied with the Falck-Hillarp technique and electron microscopy of aldehyde-OsO4or KMnO4fixed material after various types of hypothalamic deafferentation experiments with the Halász knife. Special reference was paid to the monoamine systems and the results can be summarized as follows.1.The main monoaminergic input to the ELME comes from the arcuate nucleus-periventricular area via a dorsal approach. A horizontal transection through the arcuate nucleus decreases the percentage of monoamine boutonsi.e.boutons with small granular vesicles, from 31.6% in the controls to 4.4% in the lesion group, whereas only a small effect is seen after anterior (or complete) deafferentations.2.A major input to the ELME enters the basal hypothalamus at the anterior-lateral aspects (see Réthelyi and Halász, 1970). The fibers cut after anterior deafferentations in all probability mainly come from cell bodies localized in the anterior hypothalamus or even further rostrally but some may represent NA axons ascending from the lower brain stem.3.The degeneration course of nerve endings in the ELME both after anterior deafferentations as well as after lesions in the arcuate nucleus is rapid (within 2–3 days) and morphologically characterized by an initial aggregation of large dense cored vesicles seemingly to electron dense bodies within the boutons and probably also to a closer spacing of the small electron lucent synaptic vesicles (see Raisman, 1972). This type of degeneration seems to take place both in monoamine and non-monoamine neurons.4.Degenerating boutons are found in the arcuate nucleus after anterior and complete deafferentations. Thus, the anterior hypothalamus may exert an “indirect” control of the pituitary gland via synapses on arcuate neurons although quantitatively the “direct” influence through the projection to the ELME is of more importance.5.After anterior deafferentations enlarged axons containing large amounts of large dense cored vesicles and other organelles are found caudally of the cut indicating the existence of rostral projections from the medial hypothalamus.These results have been reported in part at the 47th Annual Meeting of the Japan Endocrinological Society, April 8–10, 1974 in Tokyo.
影响因子：
1.3
作者：
Riema Abdunnur
通讯作者：
Riema Abdunnur