Modulation of gut physiology through enteric toxins
Modulation of gut physiology through enteric toxins
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DOI：
10.1023/a:1026088915240
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发表时间：
2003-11-01
影响因子：
4.3
通讯作者：
Ganguly, NK
中科院分区：
文献类型：
--
作者：
Kaur, T;Ganguly, NK
由微生物及其毒素引起的腹泻病是全世界死亡和发病的主要原因。急性腹泻主要是由于肠道分泌增加引起的，通常是由于感染产生肠毒素的微生物（产肠毒素大肠杆菌、霍乱弧菌）或由于感染损害肠上皮的微生物（致病性大肠杆菌、志贺氏菌、沙门氏菌）而导致肠道吸收减少。对肠道病原体及其毒力因子影响的研究通过产生毒素（称为细菌毒素）发挥作用。蛋白质毒素是由多种细菌产生的。大多数细菌毒素通过 ADP-核糖基化蛋白发挥作用；其他毒素对于多种细胞功能至关重要，而其他毒素则涉及鸟苷酸环化酶系统或钙和蛋白激酶以发挥其最终作用。
Diarrheal diseases caused by microorganisms and their toxins are a major cause of mortality and morbidity throughout the world. Acute diarrhea is mainly caused due to increased intestinal secretion, commonly as a result of infection with enterotoxin producing organisms (enterotoxigenic Escherichia coli, Vibrio cholera) or due to decreased intestinal absorption from infection with organisms that damage the intestinal epithelium (enteropathogenic E. coli sp., Shigella sp., Salmonella sp.) The studies of the impact of enteric pathogens and their virulence factors exert their effect by producing toxins, called bacterial toxins. The protein toxins are produced by diverse group of bacteria. Most of the bacterial toxins exert their effect through involvement of ADP-ribosylation proteins; otherwise essential for several cellular functions while other toxins involve guanylate cyclase systems or calcium and protein kinases for their ultimate action.