Low-density lipoprotein cholesterol and risk of coronary heart disease among Japanese men and women: The Circulatory Risk in Communities Study (CIRCS)
Low-density lipoprotein cholesterol and risk of coronary heart disease among Japanese men and women: The Circulatory Risk in Communities Study (CIRCS)
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DOI：
10.1016/j.ypmed.2011.02.019
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发表时间：
2011-05-01
影响因子：
5.1
通讯作者：
Iso, Hiroyasu
中科院分区：
文献类型：
--
作者：
Imano, Hironori;Noda, Hiroyuki;Iso, Hiroyasu
目标。本研究的目的是评估ldl -胆固醇水平低于西方人群的日本人血清ldl -胆固醇水平与冠心病（CHD）风险之间的关系。在参加社区循环风险研究（CIRCS）的四个日本社区的居民中，评估了随机血液样本中估计的血清ldl -胆固醇水平对冠心病风险的预测能力。共有8131名男性和女性，年龄在40至69岁之间，无卒中或冠心病病史，在1975年至1987年间完成了基线危险因素调查。截至2003年，共发现155例冠心病（心梗、心绞痛、心源性猝死）。男性的平均低密度脂蛋白胆固醇值为99.4 mg/dL，女性为109.4 mg/dL。冠心病的粗发病率（每10万人年）男性为152.0，女性为51.9。>= 140 mg/dL与< 80 mg/dL ldl -胆固醇的多变量风险比分别为：总冠心病2.80(95%可信区间：1.59 ~ 4.92)，心肌梗死3.83(1.78 ~ 8.23)，非致死性冠心病4.07(2.02 ~ 8.20)，致死性冠心病1.24（0.44 ~ 3.47）。在日本人群中，血清ldl -胆固醇水平在80 ~ 200 mg/dL之间与冠心病风险呈正相关。(C) 2011爱思唯尔公司版权所有。
Objective. The objective of this study was to assess the association between serum LDL-cholesterol levels and risk of coronary heart disease (CHD) among Japanese who have lower means of LDL-cholesterol than Western populations.Methods. The predictive power of estimated serum LDL-cholesterol levels in casual blood samples for risk of CHD was evaluated among residents from four Japanese communities participating in the Circulatory Risk in Communities Study (CIRCS). A total of 8131 men and women, aged 40 to 69 years with no history of stroke or CHD, completed baseline risk factor surveys between 1975 and 1987. By 2003, 155 cases of incident CHD (myocardial infarction, angina pectoris and sudden cardiac death) had been identified.Results. Mean LDL-cholesterol values were 99.4 mg/dL for men and 109.4 mg/dL for women. The crude incidence rate (per 100,000 person-years) of CHD was 152.0 for men and 51.9 for women. The respective multivariable hazard ratios for >= 140 mg/dL versus < 80 mg/dL LDL-cholesterol were 2.80 (95% confidence interval: 1.59 to 4.92) for total CHD, 3.83 (1.78-8.23) for myocardial infarction, 4.07 (2.02-8.20) for non-fatal CHD, and 1.24 (0.44-3.47) for fatal CHD.Conclusion. Serum LDL-cholesterol levels ranging from around 80 mg/dL to 200 mg/dL were positively associated with risk of CHD in a Japanese population. (C) 2011 Elsevier Inc. All rights reserved.