Diagnostic Accuracy of the RBANS in Mild Cognitive Impairment: Limitations on Assessing Milder Impairments
Diagnostic Accuracy of the RBANS in Mild Cognitive Impairment: Limitations on Assessing Milder Impairments
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DOI：
10.1093/arclin/acq045
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发表时间：
2010-08-01
影响因子：
2.6
通讯作者：
O'Bryant, Sid E.
中科院分区：
文献类型：
--
作者：
Duff, Kevin;Hobson, Valerie L.;O'Bryant, Sid E.
神经心理状态评估可重复电池（rban）在检测包括阿尔茨海默病在内的许多神经精神疾病的认知障碍方面表现出足够的敏感性。然而，它检测老年人轻度认知缺陷的能力尚未得到检验。目前的研究通过比较两组来检验rban的临床应用：轻度认知障碍患者（MCI; n = 72）和认知完整的患者（n = 71）。在rban总分、5项指标中的3项和12项亚测试中的6项上观察到显著差异，轻度认知障碍个体的表现比对照组参与者差。特异性很好，但敏感性从差到中等不等。rban即时记忆、延迟记忆指标和总量表得分的受试者工作特征曲线下面积较好。尽管两组之间存在显著差异，曲线下的面积也足够，但rban较低的灵敏度值表明，在诊断MCI等疾病时应谨慎使用。
The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) has demonstrated adequate sensitivity in detecting cognitive impairment in a number of neuropsychiatric conditions, including Alzheimer's disease. However, its ability to detect milder cognitive deficits in the elderly has not been examined. The current study examined the clinical utility of the RBANS by comparing two groups: Patients with Mild Cognitive Impairment (MCI; n = 72) and cognitively intact peers (n = 71). Significant differences were observed on the RBANS Total score, 3 of the 5 Indexes, and 6 of the 12 subtests, with individuals with MCI performing worse than the comparison participants. Specificity was very good, but sensitivity ranged from poor to moderate. Areas under the receiver operating characteristic curves for the RBANS Immediate and Delayed Memory Indexes and the Total Scale score were adequate. Although significant differences were observed between groups and the areas under the curves were adequate, the lower sensitivity values of the RBANS suggests that caution should be used when diagnosing conditions such as MCI.