TERATOGENICITY OF COCAINE IN HUMANS
TERATOGENICITY OF COCAINE IN HUMANS
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DOI：
10.1016/s0022-3476(87)80297-4
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发表时间：
1987-01-01
影响因子：
5.1
通讯作者：
GROMISCH, DS
中科院分区：
文献类型：
--
作者：
BINGOL, N;FUCHS, M;GROMISCH, DS
为了研究可卡因对人类的致畸作用，我们研究了三组孕妇及其子女：第一组，50名仅滥用可卡因的妇女；第二组，110名吸食多种药物的妇女；以及第三组，340名不吸毒的妇女。这三个群体在社会经济地位、吸烟和种族方面都是相似的。组1的母亲年龄与组3相似，但组2的母亲年龄明显大于组3。自然流产率三组间差异无统计学意义，但组1死产率显著高于组3(P<0.05)。0.01)。所有死产均与胎盘早剥有关。与第3组相比，第1组和第2组婴儿的出生体重、身长和头围显著减少(P0.0001)，但第1、2组间无统计学差异。第1组先天畸形率显著高于第3组(P0.01)。我们的结论是，人类滥用可卡因显著减轻胎儿体重，增加与胎盘早剥相关的死产率，并与更高的畸形率相关。
To study teratogenicity of cocaine in humans, we studied three groups of pregnant women and their offspring; group 1, 50 women who abused cocaine only; group 2, 110 women who were polydrug abusers; and group 3, 340 who were drug free. All three groups were similar for socioeconomic status, cigarette smoking, and ethnicity. Maternal age of group 1 was similar to that of group 3, but group 2 mothers were significantly older. Gravidity was significantly higher in groups 1 and 2 compared with group 3. No statistical difference was found in spontaneous abortion rate among the three groups, but the stillbirth rate was significantly higher in group 1 (.chi.2 6.89, P .ltoreq. 0.01). All stillbirths were related to abruptio placentae. Birth weight, length, and head circumference were significantly decreased in infants in groups 1 and 2 compared with group 3 (P .ltoreq. 0.0001), but no statistical difference was found between groups 1 and 2. The congenital malformation rate was significantly higher in group 1 compared with group 3 (.chi.2 = 7.07, P .ltoreq. 0.01). We conclude that cocaine abuse in humans significantly reduces weight of the fetus, increases the stillbirth rate related to abruptio placentae, and is asociated with a higher malformation rate.