Computational fluid dynamics in brain aneurysms.
Computational fluid dynamics in brain aneurysms.
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DOI：
10.1002/cnm.1481
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发表时间：
2012-06
影响因子：
2.1
通讯作者：
Cebral JR
中科院分区：
文献类型：
--
作者：
Sforza DM;Putman CM;Cebral JR
由于其处理任何几何图形的能力，基于图像的计算流体动力学（CFD）已逐渐用于研究血流动力学在控制脑动脉瘤自然历史的潜在机制中的作用。尽管在方法学发展方面取得了很大进展，许多研究使用了特定患者的数据，但关于精确的控制过程和从明显矛盾的结果中得出的不同结论仍然存在重大争议。要理清这些问题，就需要对目前的技术状况有一个全球视野，并采取统一的方法来解决这一重要的科学问题。为此，本文回顾了针对患者的CFD模型在进一步了解这些机制方面所做的贡献，并强调了针对患者的计算模型在动脉瘤破裂风险评估和患者管理方面的巨大潜力。
Because of its ability to deal with any geometry, image-based computational fluid dynamics (CFD) has been progressively used to investigate the role of hemodynamics in the underlying mechanisms governing the natural history of cerebral aneurysms. Despite great progress in methodological developments and many studies using patient-specific data, there are still significant controversies about the precise governing processes and divergent conclusions from apparently contradictory results. Sorting out these issues requires a global vision of the state of the art and a unified approach to solving this important scientific problem. Towards this end, this paper reviews the contributions made using patient-specific CFD models to further the understanding of these mechanisms, and highlights the great potential of patient-specific computational models for clinical use in the assessment of aneurysm rupture risk and patient management.