Effects of morphine and its withdrawal on Y-maze spatial recognition memory in mice
Effects of morphine and its withdrawal on Y-maze spatial recognition memory in mice
复制标题
吗啡及其戒断对小鼠 Y 迷宫空间识别记忆的影响
DOI：
10.1016/j.neuroscience.2007.05.020
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发表时间：
2007-07-29
期刊：
影响因子：
3.3
通讯作者：
Wang, J. H.
中科院分区：
文献类型：
--
作者：
Ma, M. X.;Chen, Y. M.;Wang, J. H.
Effects of morphine on acquisition and retrieval of memory have been proven in the avoidance paradigms. In present study, we used a two-trial recognition Y-maze to test the effects of acute morphine and morphine withdrawal on spatial recognition memory. The Y-maze is based on the innate tendency of rodents to explore novel environments and therefore avoid punishment and reward. Results: 1) Pre-training morphine 10 mg/kg impaired the recognition spatial memory of acquisition after a 1 h inter-trial interval (ITI), whereas morphine 2.5, 5 and 10 mg/kg showed impairment after 2 h ITI. 2) Preretention morphine 5, 10 mg/kg disrupted the retrieval of memory after 1 h ITI. 3) Morphine 5 and 10 mg/kg caused hyperlocomotor activity depending on the state. 4) Mice withdrawn from morphine 40 mg/kg but not 10 mg/kg for 3 days showed amnesia in Y-maze. Our data suggested that acute morphine impaired the acquisition and retrieval of spatial recognition memory and increased the locomotor activity in the Y-maze depending on the dose and state. Moreover, withdrawal from chronic morphine also impaired acquisition in the Y-maze depending on the dose and state. (C) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.
