SAMPLE-SIZE DETERMINATION FOR PAIR-MATCHED CASE CONTROL STUDIES WHERE THE GOAL IS INTERVAL ESTIMATION OF THE ODDS RATIO
SAMPLE-SIZE DETERMINATION FOR PAIR-MATCHED CASE CONTROL STUDIES WHERE THE GOAL IS INTERVAL ESTIMATION OF THE ODDS RATIO
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DOI：
10.1016/0895-4356(90)90056-u
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发表时间：
1990-01-01
影响因子：
7.2
通讯作者：
KUPPER, LL
中科院分区：
文献类型：
--
作者：
SATTEN, GA;KUPPER, LL
对于采用1:1匹配的病例对照研究，计算样本量，其目标是比值比的区间估计。最优样本量定义为100（1-.alpha。）对数比值比的%置信区间不会超过2.delta指定的值。具有指定的概率（1-.gamma.）。当以显著性测试为目标时，这种方法在精神上类似于基于权力的样本大小确定方法。给出了各种参数选择的样本量表。我们还发现，基于不一致对的预期数量的已发表方法存在相当大的分歧。
Sample sizes are calculated for case-control studies where 1:1 matching has been employed, and where the goal is the interval estimation of the odds ratio. The optimal sample size is defined to be the smallest value for which a 100(1-.alpha.)% confidence interval for the log odds ratio will not exceed a specified with 2.delta. with specified probability (1-.gamma.). This approach is similar in spirit to the power-based approach for sample size determination when significance testing is the goal. Tables of sample sizes are presented for various choices of parameters. We also find considerable disagreement with a published method based on expected numbers of discordant pairs.