A phenotypically distinct subset of immature B cells exhibits partial activation, increased survival, and preferential expression of VhS107.
A phenotypically distinct subset of immature B cells exhibits partial activation, increased survival, and preferential expression of VhS107.
复制标题
未成熟 B 细胞的表型独特的子集表现出部分激活、存活增加和 VhS107 的优先表达。
DOI：
10.1002/eji.200324324
复制
发表时间：
2003
影响因子：
5.4
通讯作者：
Riley,RichardL
中科院分区：
文献类型：
--
作者：
Wilson,EmilyL;Sherwood,ErinM;King,AnneM;Riley,RichardL
We have observed that immature B cells (IgMlowIgD–) in the bone marrow of adult BALB/c mice exhibit heterogeneity, with a distinct subpopulation (∼4–10%) expressing the CD43/S7 surface protein. These CD43/S7+immature B cells often express other surface antigens associated with B cell activation (CD5, CD11b, PD‐1). Generation of optimal numbers of CD43/S7+immature B cells requires expression of a functional Btk protein, consistent with activation as a requisite for the CD43/S7+immature B cell phenotype. Like typical CD43/S7–immature B cells, the CD43/S7+immature B cells are predominantly resting cells, which are derived from cycling bone marrow B cell precursors. The CD43/S7+immature B cell population exhibits enhanced survivalin vivoupon administration of the apoptosis‐inducing corticosteroid, dexamethasone. Finally, CD43/S7+immature B cells show a fourfold increase in incidence of VhS107 μ heavy chain expression compared to the CD43/S7–immature B cells. Therefore, in adult murine bone marrow, the presence of a phenotypically distinct immature B cellpopulation can be demonstrated which has undergone partial activation leading to increased survival and BCR‐dependent Vh repertoire selection.
