Robust flow measurement with multi-exposure speckle imaging
Robust flow measurement with multi-exposure speckle imaging
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DOI：
10.1364/oe.16.001975
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发表时间：
2008-02-04
期刊：
影响因子：
3.8
通讯作者：
Dunn, Andrew K.
中科院分区：
文献类型：
--
作者：
Parthasarathy, Ashwin B.;Tom, W. James;Dunn, Andrew K.
激光散斑对比成像（LSCI）是一种用于生成高空间和时间分辨率的血流图的微创全场光学技术。缺乏定量准确性和无法预测静态散射物（如完整或变薄的颅骨）下的血流是LSCI的主要限制。我们提出了一种新的多曝光散斑成像（MESI）仪器，它有可能获得定量的基线流量测量。我们表明MESI仪器扩展了相对流量测量是线性的范围。我们还提出了一个新的散斑模型，该模型可以在静态散射存在的情况下区分流动。我们发现，在静态散射体存在的情况下，与新的MESI仪器一起使用的新模型可以一致地预测流量的相关次数，其值与没有静态散射体的值的平均偏差在10%以内，而使用传统LSCI的平均偏差超过100%。我们还表明，MESI仪器使用的新散斑模型可以在静态散射体存在的情况下保持相对流量测量的线性。(C) 2008美国光学学会。
Laser Speckle Contrast Imaging (LSCI) is a minimally invasive full field optical technique used to generate blood flow maps with high spatial and temporal resolution. The lack of quantitative accuracy and the inability to predict flows in the presence of static scatterers such as an intact or thinned skull have been the primary limitation of LSCI. We present a new Multi-Exposure Speckle Imaging (MESI) instrument that has potential to obtain quantitative baseline flow measures. We show that the MESI instrument extends the range over which relative flow measurements are linear. We also present a new speckle model which can discriminate flows in the presence of static scatters. We show that in the presence of static scatterers the new model used along with the new MESI instrument can predict correlation times of flow consistently to within 10% of the value without static scatterers compared to an average deviation of more than 100% from the value without static scatterers using traditional LSCI. We also show that the new speckle model used with the MESI instrument can maintain the linearity of relative flow measurements in the presence of static scatterers. (C) 2008 Optical Society of America.