Gingival crevicular fluid monocyte chemoattractant protein-1 and RANTES levels in patients with generalized aggressive periodontitis
Gingival crevicular fluid monocyte chemoattractant protein-1 and RANTES levels in patients with generalized aggressive periodontitis
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DOI：
10.1111/j.1600-051x.2004.00584.x
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发表时间：
2004-10-01
影响因子：
6.7
通讯作者：
Hüseyinov, A
中科院分区：
文献类型：
--
作者：
Emingil, G;Atilla, G;Hüseyinov, A
背景资料：局部和全身炎症和免疫机制可能与牙周病侵袭性形式的发病机制有关。趋化因子，单核细胞趋化蛋白-1（MCP-1）和受活化调节的正常T细胞表达和分泌RANTES（受活化调节的正常T细胞表达和分泌），参与炎症和免疫细胞的活化和募集至感染部位，从而介导多种病理生理学状况。本研究旨在检测泛发性侵袭性牙周炎（G-AgP）患者龈沟液（GCF）中单核细胞趋化蛋白-1（MCP-1）和RANTES的水平。牙周状况通过测量探诊深度、临床附着丧失、探诊出血和斑块的存在来评估。在G-AgP组中，GCF样品从两个邻近部位收集;从一个单根牙和一个第一磨牙，探测深度大于或等于6 mm。在健康组中，GCF样品从其中一个单根牙收集。结果：G-AgP患者GCF MCP-1和RANTES水平显著高于健康对照组（P
Background: Local and systemic inflammatory and immune mechanisms may be implicated in the pathogenesis of the aggressive forms of periodontal disease. Chemokines, monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cells expressed and secreted RANTES (regulated on activation, normal T cells expressed and secreted), are involved in the activation and recruitment of inflammatory and immune cells to the infected sites and thereby mediating a variety of pathophysiological conditions. The aim of the present study was to examine the gingival crevicular fluid (GCF) levels of MCP-1 and RANTES in patients with generalized agressive periodontitis (G-AgP).Methods: MCP-1 and RANTES levels were investigated in GCF samples of 10 patients with G-AgP and 10 periodontally healthy subjects. Periodontal status was evaluated by measuring probing depth, clinical attachment loss, presence of bleeding on probing and plaque. In the G-AgP group, GCF samples were collected from the two approximal sites; from one single-rooted tooth and from one first molar tooth with greater than or equal to6 mm probing depth. In the healthy group, GCF samples were collected from one of the single-rooted teeth. GCF MCP-1 and RANTES levels were quantified by enzyme immunoassay.Results: The G-AgP patients had significantly higher GCF MCP-1 and RANTES levels compared to the healthy group (p