D1-LIKE DOPAMINE RECEPTOR DYSFUNCTION IN THE LATERAL HABENULA NUCLEUS INCREASED ANXIETY-LIKE BEHAVIOR IN RAT
D1-LIKE DOPAMINE RECEPTOR DYSFUNCTION IN THE LATERAL HABENULA NUCLEUS INCREASED ANXIETY-LIKE BEHAVIOR IN RAT
复制标题
外侧缰核中的 D1 样多巴胺受体功能障碍增加了大鼠的焦虑样行为
DOI：
10.1016/j.neuroscience.2016.11.005
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发表时间：
2017-01-06
期刊：
影响因子：
3.3
通讯作者：
Chen, Yanmei
中科院分区：
文献类型：
--
作者：
Chan, Jiangping;Ni, Yiling;Chen, Yanmei
外侧缰核 (LHb) 对于情绪处理很重要。它是前脑和中脑之间的连接节点。 LHb 与腹侧被盖区相互连接，充当多巴胺能系统的调节中心。然而，LHb 中的多巴胺受体在情绪处理中的作用尚不清楚。本研究通过蛋白质印迹法证实LHb中多巴胺D1和D2受体的表达。此外，将D1或D2样受体激动剂或拮抗剂注射到LHb双侧，15分钟后在大鼠中测试焦虑样和抑郁样行为。此外，还评估了 LHb 多巴胺受体激活和失活对厌恶性学习和记忆的影响。我们的结果表明：（1）LHb 中 D1R（而非 D2R）的激活和抑制会增加大鼠的焦虑样行为，但会减少抑郁样行为。 (2) LHb中D1R的激活和失活损害了大鼠的厌恶性记忆获取，但不损害巩固，D1R激动剂也损害了大鼠的厌恶性记忆检索。这些结果可能为 LHb 如何参与情绪处理提供新线索。 (C) 2016 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
Lateral habenula (LHb) is important for emotional processing. It is a link node between forebrain and midbrain. LHb is reciprocally connected with ventral tegmental area, acting as a regulatory center for the dopaminergic system. However, the role of dopamine receptors in the LHb in emotional processing is less clear. In the present study, the expression of dopamine D1 and D2 receptors in LHb was testified by western blot. In addition, D1- or D2-like receptor agonist or antagonist was bilaterally administered into the LHb, anxiety-like and depressive-like behaviors were tested 15 min later in rats. In addition, the effects of LHb dopamine receptor activation and inactivation on aversive learning and memory were assessed. Our results showed that: (1) activation and inhibition of D1R but not D2R in LHb increased anxiety-like behavior but decreased depressive like behavior in rats. (2) D1R activation and inactivation in LHb impaired aversive memory acquisition but not consolidation in rats, D1R agonist also impaired aversive memory retrieval in rats. These results might provide new clues about how LHb was involved in emotional processing. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.