Frontal Feedback-Related Potentials in Nonhuman Primates: Modulation during Learning and under Haloperidol
Frontal Feedback-Related Potentials in Nonhuman Primates: Modulation during Learning and under Haloperidol
复制标题
非人类灵长类动物的额反馈相关电位：学习期间和氟哌啶醇的调节
作者：
J. Vezoli;E. Procyk
反馈监测和性能的适应涉及一个内侧奖励系统，包括内侧额叶皮质区，内侧纹状体和多巴胺能系统。在人类的额面反馈相关电位（FRPs）和猴子的结果监测与单个单位活动的相关性方面，已经获得了相当多的数据。然而，还需要开展工作，以弥合在这两个物种中获得的知识。目前的工作描述了FRPs在猴子，使用慢性录音，在一个试验和错误的任务。我们发现，正面的FRPs是不同的敏感性，成功和失败，可以观察到在长期的时间。此外，使用多巴胺拮抗剂氟哌啶醇，我们观察到的选择性影响FRP振幅是不存在的纯感觉相关电位。这些结果描述了猴子的额叶多巴胺能依赖性FRPs，并证实了人猴同源性的性能监测信号。
Feedback monitoring and adaptation of performance involve a medial reward system including medial frontal cortical areas, the medial striatum, and the dopaminergic system. A considerable amount of data has been obtained on frontal surface feedback-related potentials (FRPs) in humans and on the correlate of outcome monitoring with single unit activity in monkeys. However, work is needed to bridge knowledge obtained in the two species. The present work describes FRPs in monkeys, using chronic recordings, during a trial and error task. We show that frontal FRPs are differentially sensitive to successes and failures and can be observed over long-term periods. In addition, using the dopamine antagonist haloperidol we observe a selective effect on FRP amplitude that is absent for pure sensory-related potentials. These results describe frontal dopaminergic-dependent FRPs in monkeys and corroborate a human-monkey homology for performance monitoring signals.
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未接触过药物的猴子体内的多巴胺 D1 (SCH 23390) 和 D2（氟哌啶醇）拮抗剂。
影响因子：
3.4
作者：
Casey,DE
通讯作者：
Casey,DE
影响因子：
3.7
作者：
Yeung, N;Holroyd, CB;Cohen, JD
通讯作者：
Cohen, JD
DOI：
10.1073/pnas.91.10.4353
发表时间：
1994-05-10
影响因子：
11.1
作者：
LIDOW, MS;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS
影响因子：
56.9
作者：
Castner, SA;Williams, GV;Goldman-Rakic, PS
通讯作者：
Goldman-Rakic, PS