A Novel Coronavirus from Patients with Pneumonia in China, 2019
A Novel Coronavirus from Patients with Pneumonia in China, 2019
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DOI：
10.1056/nejmoa2001017
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发表时间：
2020-02-20
影响因子：
158.5
通讯作者：
Tan, Wenjie
中科院分区：
文献类型：
--
作者：
Zhu, Na;Zhang, Dingyu;Tan, Wenjie
2019年12月，一群不明原因的肺炎患者与中国武汉的一个海鲜批发市场有关。通过对肺炎患者样本进行无偏测序，发现了一种以前未知的β冠状病毒。使用人气道上皮细胞分离出一种新型冠状病毒，命名为2019-nCoV，它形成了Sarbecovirus亚属，Orthocoronavirinae亚科的一个分支。与MERS-CoV和SARS-CoV不同，2019-nCoV是感染人类的冠状病毒家族的第七个成员。目前正在加强监测和进一步调查。（由国家重点研究发展计划和国家传染病防治重大专项资助）作者报告了一种以前未知的β冠状病毒的出现和分离，这是中国武汉感染人类的冠状病毒家族的第七个成员。在三个病人的调查结果进行了描述。
In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.)The authors report the emergence and isolation of a previously unknown betacoronavirus, the seventh member of the family of coronaviruses that infect humans, in Wuhan, China. Findings in three patients are described.