Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14.
Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14.
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编码多功能钙/钙调蛋白依赖性蛋白激酶（CaM 激酶）γ亚型的 CAMKG 基因定位于人 10 号染色体带 q22 和小鼠 14 号染色体。
DOI：
10.1159/000133679
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Francke,U
中科院分区：
文献类型：
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作者：
Li,X;Nghiem,P;Schulman,H;Francke,U
多功能钙/钙调蛋白依赖性蛋白激酶（CaM kinase）是一种介导钙依赖性信号转导途径的酶。CaM激酶以多种亚型存在，每种亚型具有不同的组织特异性表达模式，这使得激酶能够调节哺乳动物系统中的多种功能。本文报道了已克隆的人γ-CaM激酶基因（CAMKG）的染色体定位。应用人×中国仓鼠体细胞杂交作图板和荧光原位杂交技术，将人CAMKG定位于染色体10 q22。我们克隆了小鼠γ-CaM激酶基因的一部分，并通过分析一组小鼠×啮齿动物体细胞杂种系将其定位于小鼠14号染色体上。一个隐性基因，阿萨，牵连在控制自身免疫反应，位于预测区域为Camkg。
Multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) is an enzyme mediating calcium-dependent signal transduction pathways. CaM kinase exists in a variety of isoforms, each with a distinct tissue-specific expression pattern, that enables the kinase to regulate multiple functions in mammalian systems. Here we report the chromosomal localization of the previously cloned human γ-CaM kinase gene (CAMKG). By using a mapping panel of human × Chinese hamster somatic cell hybrid lines and fluorescence in situ hybridization, we have assigned human CAMKG to chromosome 10q22. We have partially cloned the murine γ-CaM kinase gene and mapped itCamkgto mouse chromosome 14 by analyzing a panel of mouse × rodent somatic cell hybrid lines. A recessive gene,asa,implicated in the control of autoimmune response, is located within the predicted region forCamkg.