Spread of multidrug-resistant clonal complex 271 of serotype 19F Streptococcus pneumoniae in Beijing, China: characterization of serotype 19F
Spread of multidrug-resistant clonal complex 271 of serotype 19F Streptococcus pneumoniae in Beijing, China: characterization of serotype 19F
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DOI：
10.1017/s0950268813000514
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发表时间：
2013-12-01
影响因子：
4.2
通讯作者：
Yang, Y. H.
中科院分区：
文献类型：
--
作者：
Li, Q. H.;Yao, K. H.;Yang, Y. H.
我们对1997-2006年和2010年收集的120株19F肺炎链球菌的基因结构进行了研究。所有菌株对万古霉素和左氧氟沙星敏感，只有5株对青霉素不敏感。从1997年到2010年，头孢菌素类药物的不敏感率有所上升。在119株红霉素耐药株中，60株同时携带ermB和mefA基因。克隆复合体271(CC271)的比例从1997-1998年的14.3%上升到2010年的92%，而CC983的比例从64.3%下降到0%。CC271对β-内酰胺类抗生素的不敏感率高于CC983和其他CCS。在19F型肺炎球菌中，对β-内酰胺类抗生素不敏感率的增加被发现与国际耐药克隆CC271的传播有关，推测是由抗生素压力引起的。需要对19F肺炎链球菌进行长期调查，以监测CC的流行情况和耐药性的趋势。
We investigated the genetic structure of 120 isolates of serotype 19F Streptococcus pneumoniae from Chinese children with acute respiratory infections collected from 1997 to 2006, and 2010. All strains were susceptible to vancomycin and levofloxacin, and only five strains were not susceptible to penicillin. The non-susceptibility rate to cephalosporins increased from 1997 to 2010. Of 119 erythromycin-resistant strains, 60 carried both ermB and mefA genes. The percentage of clonal complex 271 (CC271) increased from 14.3% in 1997-1998 to 92% in 2010, whereas that of CC983 decreased from 64.3% to 0%. CC271 had a higher non-susceptibility rate to beta-lactam antibiotics than CC983 and other CCs. The increased non-susceptibility rate to beta-lactam antibiotics in serotype 19F pneumococci was found to be associated with the spread of the international resistant clone CC271 presumably caused by antibiotic pressure. Long-term surveys of serotype 19F S. pneumoniae are required to monitor CC prevalence and trends in antimicrobial resistance.