Antiviral RNA recognition and assembly by RLR family innate immune sensors.
Antiviral RNA recognition and assembly by RLR family innate immune sensors.
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DOI：
10.1016/j.cytogfr.2014.07.006
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发表时间：
2014-10
影响因子：
13
通讯作者：
Horvath, Curt M.
中科院分区：
文献类型：
--
作者：
Bruns, Annie M.;Horvath, Curt M.
病毒编码的分子特征，如胞质双链或其他生物化学上不同的RNA物种，触发细胞抗病毒信号。细胞质蛋白识别这些非自身RNA，激活信号转导通路，驱动病毒诱导的基因表达，包括主要的抗病毒细胞因子干扰素β，以及各种直接和间接的抗病毒效应。一组重要的胞质RNA传感器被称为RIG-I样受体(RLRs)，由三种结构和功能相似的蛋白质组成。RLR蛋白RIG-I、MDA5和LGP2具有识别病毒感染产生的核酸信号并激活抗病毒信号的能力。新的证据表明，RLRs对RNA的检测最终会导致动态多聚体核糖核蛋白(RNP)复合体的组装。这些RNP可以作为信号平台，能够传播和放大抗病毒信号反应。尽管RLRs具有相同的结构域结构和相似的诱导抗病毒反应的能力，但它们在酶性质、识别RNA的内在能力和组装成丝状复合体的能力上存在差异。这种分子特化使RLRs能够识别和响应不同的病毒感染，并在免疫调节中调节独特和重叠的功能。
Virus-encoded molecular signatures, such as cytosolic double-stranded or otherwise biochemically distinct RNA species, trigger cellular antiviral signaling. Cytoplasmic proteins recognize these non-self RNAs and activate signal transduction pathways that drive the expression of virus-induced genes, including the primary antiviral cytokine, IFNβ, and diverse direct and indirect antiviral effectors. One important group of cytosolic RNA sensors known as the RIG-I like receptors (RLRs) is comprised of three proteins that are similar in structure and function. The RLR proteins, RIG-I, MDA5, and LGP2, share the ability to recognize nucleic acid signatures produced by virus infections and activate antiviral signaling. Emerging evidence indicates that RNA detection by RLRs culminates in the assembly of dynamic multimeric ribonucleoprotein (RNP) complexes. These RNPs can act as signaling platforms that are capable of propagating and amplifying antiviral signaling responses. Despite their common domain structures and similar abilities to induce antiviral responses, the RLRs differ in their enzymatic properties, their intrinsic abilities to recognize RNA, and their ability to assemble into filamentous complexes. This molecular specialization has enabled the RLRs to recognize and respond to diverse virus infections, and to mediate both unique and overlapping functions in immune regulation.
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影响因子：
64.8
作者：
Jiang, Fuguo;Ramanathan, Anand;Miller, Matthew T.;Tang, Guo-Qing;Gale, Michael, Jr.;Patel, Smita S.;Marcotrigiano, Joseph
通讯作者：
Marcotrigiano, Joseph
影响因子：
8.8
作者：
Feng Q;Hato SV;Langereis MA;Zoll J;Virgen-Slane R;Peisley A;Hur S;Semler BL;van Rij RP;van Kuppeveld FJ
通讯作者：
van Kuppeveld FJ
影响因子：
3.5
作者：
Baum, Alina;Garcia-Sastre, Adolfo
通讯作者：
Garcia-Sastre, Adolfo
影响因子：
3.7
作者：
Childs KS;Randall RE;Goodbourn S
通讯作者：
Goodbourn S
影响因子：
4.8
作者：
Bamming, Darja;Horvath, Curt M.
通讯作者：
Horvath, Curt M.